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EC number: 256-360-6 | CAS number: 48145-04-6
The dermal irritation of 2-phenoxyethyl acrylate was investigated in two studies, both showing no/slight irritation. A short term study (4 hours exposure) on dermal irritation found that 2-phenoxyethyl acrylate was not irritating. In the key study (24 hour exposure study with 72 hour follow up) sligth reversible irritation was observed,, dermal reactions were observed only in two out of six animals, and with the dermal irritation index of 0.25. The major criteria for a classification as skin irritant is therefor not met.The eye irritation of 2-phenoxyethyl acrylate was investigated in a rabbit study, showing light irrittion. The major criteria for a classification as eye irritant is therefore not met.
The skin irritation potential of 2-phenoxyethyl acrylate was investigated on intact and abraded skin on rabbits. A single occlusive application for 24 hours elicited very slight dermal irritation, in two out of six animals. Primary irritation index was calculated to be 0.25. and 2-phenoxyethyl acrylate is therefore not a skin irritant. Hence, no classification is needed.
The eye irritation potential of 2 -phenoxyethyl acrylate were investigated in rabbits following the draize test. The substance was shown to be slightly irritating, but fully reversible after 48 hours.
The available experimental data suggest that 2-phenoxyethyl acrylate is not corrosive, as all observed effects were fully reversible.
The key study on dermal irritation found that only two of six animal had dermal reactions, leading to a primary irritation index of 0.25. The major criteria for classification as irritant is therefore not met ( at least two of three animals, with a mean score between 2.3 to 4.0). Supplementary information from another non-GLP skin irritation study in rabbits (BASF_1982) showed reactions to intact and abreaded skin. After 8 days, erythema (score 2; max score 3) was not reversible in 2/6 animals on intact skin. In contrast, edema (score 1.6; max score 3) was fully reversible after 8 days in all animals. For erythema (score 2.5; max score 3) was not fully reversible on abreaded skin after 8 days (3/6).
The data from the study available on eye irritation (BASF_1981) shows that all animals have ligth redness, score 1, which is fully reversible after 48 hours, where only one animal show ligthly increased redness. Supplementary information from another non-GLP eye irritation study in rabbits (BASF_1982) shows a max conjunctivae scores of 1 (medium of 0.39) which was fully reversible within the observation period.
Justification for selection of skin irritation / corrosion endpoint: This is the most recent study, performed according to GLP, and of longer duration than the study from 1994 Justification for selection of eye irritation endpoint: The only study available on eye irritation Effects on skin irritation/corrosion: slightly irritating Effects on eye irritation: slightly irritating
A short term study (4 hours exposure) on dermal irritation found that 2-phenoxyethyl acrylate was not irritating. In the key study (24 hour exposure study with 72 hour follow up) sligth reversible irritation was observed,, dermal reactions were observed only in two out of six animals, and with the dermal irritation index of 0.25. The major criteria for a classification as skin irritant is therefor not met.
For classification as an eye irritant the criteria are also not met, as reactions observed were fully reversible, and mean scores following grading 24, 48, and 72 hours were lower than the criteria set in table 3.3.2 in Regulation (ec) 1272/2008.
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