2-phenoxyethyl acrylate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: basic information given

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1982

Report date:

1982

Materials and methods

Principles of method if other than guideline:

according to Smyth, H.F. et al.: Am. Ind. Hyg. Ass. J. 23, 95-107 (1962)

GLP compliance:

no

Test type:

other: inhalation hazard test

Test material

Test material information

Constituent 1

Reference substance name:

2-phenoxyethyl acrylate

EC Number:

256-360-6

EC Name:

2-phenoxyethyl acrylate

Cas Number:

48145-04-6

Molecular formula:

C11H12O3

IUPAC Name:

2-phenoxyethyl prop-2-enoate

Details on test material:

Name of the test substance used in the study report: 2-Phenoxyethylacrylat
Purity: ca. 70%
Remaining acrylic acid < 1%

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

Acclimatization period: at least 5 days
Age at study start: 7 - 10 weeks
Body weight at study start: 180 - 250 g
Animal identification: toe amputation
3 animals per cage (wire mesh cages; type Becker D III)
Housing conditions: room temperature 22 +/- 2°C, relative humidity 55 +/- 5%, day/night rhythm 12 h/12 h
The animals were offered a standardized animal laboratory diet ad libitum; drinking water: daily 250 ml/cage

Administration / exposure

Route of administration:

inhalation

Details on inhalation exposure:

The product was filled in a glass bottle to a height of 5 cm (fritted glas flask, pore size 90 - 150 um, diameter 30 mm), and the net weight was determined.
A stream of 200 l/h compressed air was supplied to the fritted glass flask containing the product, which had been placed in a water bath maintained at 20 ± 1°C by a thermostat. The mixture of air and test substance generated in this way was passed through a glass distributor to 6 glass tubes in which 3 male and 3 female animals had been placed. The emerging mixtures of test substance and air were exhausted.
After 30 minutes, the fritted glass flask was replaced by a new one filled with fresh test substance as described above. This receiver was then used for the whole remaining time of the test.
The test substance consumed was determined by reweighing the fritted glass flasks. The exposure time was 7 hours. The intention was to determine the exposure time which was survived by all the animals including a post-exposure observation period lasting 14 days in 2 experiments.

Duration of exposure:

7 h

Concentrations:

not given

No. of animals per sex per dose:

6

Details on study design:

Clinical signs or lethality of the animals were recorded daily.
The animals that died or those sacrificed with carbon dioxide at the end of the post-exposure observation period were subjected to a gross-pathological examination.

Results and discussion

Mortality:

None

Clinical signs:

other: During exposure: restlessness, snout wiping After exposure: no abnormalities detected

Gross pathology:

Organs: nothing abnormal detected

Applicant's summary and conclusion

Conclusions:

No clear conclusion from this study can be made as exposure concentration was not given.