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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: basic information given

Data source

Reference Type:
study report
Report date:

Materials and methods

Principles of method if other than guideline:
according to Smyth, H.F. et al.: Am. Ind. Hyg. Ass. J. 23, 95-107 (1962)
GLP compliance:
Test type:
other: inhalation hazard test

Test material

Constituent 1
Chemical structure
Reference substance name:
2-phenoxyethyl acrylate
EC Number:
EC Name:
2-phenoxyethyl acrylate
Cas Number:
Molecular formula:
2-phenoxyethyl prop-2-enoate
Details on test material:
Name of the test substance used in the study report: 2-Phenoxyethylacrylat
Purity: ca. 70%
Remaining acrylic acid < 1%

Test animals

Details on test animals or test system and environmental conditions:
Acclimatization period: at least 5 days
Age at study start: 7 - 10 weeks
Body weight at study start: 180 - 250 g
Animal identification: toe amputation
3 animals per cage (wire mesh cages; type Becker D III)
Housing conditions: room temperature 22 +/- 2°C, relative humidity 55 +/- 5%, day/night rhythm 12 h/12 h
The animals were offered a standardized animal laboratory diet ad libitum; drinking water: daily 250 ml/cage

Administration / exposure

Route of administration:
Details on inhalation exposure:
The product was filled in a glass bottle to a height of 5 cm (fritted glas flask, pore size 90 - 150 um, diameter 30 mm), and the net weight was determined.
A stream of 200 l/h compressed air was supplied to the fritted glass flask containing the product, which had been placed in a water bath maintained at 20 ± 1°C by a thermostat. The mixture of air and test substance generated in this way was passed through a glass distributor to 6 glass tubes in which 3 male and 3 female animals had been placed. The emerging mixtures of test substance and air were exhausted.
After 30 minutes, the fritted glass flask was replaced by a new one filled with fresh test substance as described above. This receiver was then used for the whole remaining time of the test.
The test substance consumed was determined by reweighing the fritted glass flasks. The exposure time was 7 hours. The intention was to determine the exposure time which was survived by all the animals including a post-exposure observation period lasting 14 days in 2 experiments.
Duration of exposure:
7 h
not given
No. of animals per sex per dose:
Details on study design:
Clinical signs or lethality of the animals were recorded daily.
The animals that died or those sacrificed with carbon dioxide at the end of the post-exposure observation period were subjected to a gross-pathological examination.

Results and discussion

Clinical signs:
other: During exposure: restlessness, snout wiping After exposure: no abnormalities detected
Gross pathology:
Organs: nothing abnormal detected

Applicant's summary and conclusion

No clear conclusion from this study can be made as exposure concentration was not given.