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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Remarks:
Scientifically reliable.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977
Report date:
1977

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
not specified
Principles of method if other than guideline:
No further information available.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
3,6,9,12-tetraoxotridecanol
EC Number:
245-883-5
EC Name:
3,6,9,12-tetraoxotridecanol
Cas Number:
23783-42-8
Molecular formula:
C9H20O5
IUPAC Name:
2,5,8,11-tetraoxatridecan-13-ol
Test material form:
liquid
Details on test material:
- Physical state: colorless liquid

Test animals

Species:
rat
Strain:
Wistar
Sex:
female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 98 - 116 g (average weight 109 g)
- Fasting period before study: 16 hours
- Housing: wood shavings
- Diet (e.g. ad libitum): 2 hours after administration of the product the animals were again given food. The animals received as lining the lialtungsdiät Altromin Altromin 1324 the Company GmbH, Lage / Lippe ad libitum
- Water: ad libitum

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Doses:
Single dose
No. of animals per sex per dose:
10
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: weekly
- Necropsy of survivors performed: yes, after the end of follow-up rats were killed under anesthesia, dissected and macroscopically evaluated.

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
> 15 000 mg/kg bw
Based on:
test mat.
Mortality:
1/10 died.
Clinical signs:
other: Animals exposed to 15,000 mg/kg exhibited staggering gait, ruffled fur, gasping respiration
Gross pathology:
The autopsy of the deceased animal at the end of test was macroscopically evaluated without specific findings.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: not specified
Executive summary:

In an acute oral toxicity study in rats that approximated to guideline, an LD50 of >15000mg/kg was established for the substance methyl tetraglycol.