Registration Dossier
Registration Dossier
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EC number: 245-883-5 | CAS number: 23783-42-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- Scientifically reliable.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- Principles of method if other than guideline:
- No further information available.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 3,6,9,12-tetraoxotridecanol
- EC Number:
- 245-883-5
- EC Name:
- 3,6,9,12-tetraoxotridecanol
- Cas Number:
- 23783-42-8
- Molecular formula:
- C9H20O5
- IUPAC Name:
- 2,5,8,11-tetraoxatridecan-13-ol
- Test material form:
- liquid
- Details on test material:
- - Physical state: colorless liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 98 - 116 g (average weight 109 g)
- Fasting period before study: 16 hours
- Housing: wood shavings
- Diet (e.g. ad libitum): 2 hours after administration of the product the animals were again given food. The animals received as lining the lialtungsdiät Altromin Altromin 1324 the Company GmbH, Lage / Lippe ad libitum
- Water: ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Doses:
- Single dose
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: weekly
- Necropsy of survivors performed: yes, after the end of follow-up rats were killed under anesthesia, dissected and macroscopically evaluated.
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 15 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 1/10 died.
- Clinical signs:
- other: Animals exposed to 15,000 mg/kg exhibited staggering gait, ruffled fur, gasping respiration
- Gross pathology:
- The autopsy of the deceased animal at the end of test was macroscopically evaluated without specific findings.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
- Executive summary:
In an acute oral toxicity study in rats that approximated to guideline, an LD50 of >15000mg/kg was established for the substance methyl tetraglycol.
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