Registration Dossier
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EC number: 245-883-5 | CAS number: 23783-42-8
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
DEGME, Measured EC0 (72hr) >1000mg/l QSAR: prediction EC0 (96hr)=900mg/l, EC50=6600mg/l
TEGME: Measured EC20(72hr) >500mg/L, QSAR prediction EC0 (96hr)=1800mg/L, EC50=14100mg/L
TetraEGME QSAR prediction EC0 (96hr) = 3400mg/L, EC50=27600mg/L.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 27 600 mg/L
- EC10 or NOEC for freshwater algae:
- 3 400 mg/L
Additional information
In a growth inhibition acute toxicity test, the green algae Scenedesmus subspicatus were exposed to concentrations of 2 -(2 -(2 -methoxyethoxy)ethoxy)ethanol at concentrations up to 500mg/l for a period of 72 hours. No growth inhibition was seen, indicating that the substance is practically non-toxic to algae. Whilst only an EC20 is quoted (>500mg/l), it is assumed based on information available in this and other studies that this would be the same as the EC10. This result is supported by information from the ECOSAR QSAR model, which predicts that the 96hr EC50 value for algae would be 14100mg/l and the 96hr NOEC 1800mg/l. The toxicity of this homologous series is predicted to decrease with increasing molecular weight with TetraEGME having EC50/10 values double those of TEGME. The NOEC value for DEGME does not appear to be underestimated based on the measured data. Therefore the QSAR values are used as a basis for the EC50 and EC10 values.
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