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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

ORAL - RATS (mg/kg)

TetraEGME LD50: 15000 mg/kg; LD0 5000mg/kg

Supporting information:

TEGME: LD50: >10500, 11.3ml/kg

Mix of tri, tetra and penta methyls: >5000mg/kg, 10760-13450 mg/kg.  LD0: 5ml/kg, 5g/kg

DERMAL LD50 (mg/kg)

TEGME: Rabbit: 7100mg/kg

Rat: Mix of tri, tetra and penta methyls: Rat LD0: >2000mg/kg

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
10 500 mg/kg bw

Additional information

A number of LD50 studies are available in rats using the substances methyl triglycol and methyl tetraglycol. The key study selected shows that the LD50 exceeds 10500mg/kg.

Acute dermal toxicity data is available in both the rat and rabbit for tri and tetraethylene glycol methyl ether and formulations containing these substances. An LD50 of ~7.5mg/kg was established in the rabbit whilst a figure of >2000mg/kg was established in the rat from a recent GLP limit study using a mixture of primarily tri, tetra and penta ethylene glycol methyl ethers. In a sub-chronic dermal toxicity study using rats (reported in chapter 7.5.2) a NOAEL of 4000mg/kg was established, indicating that the acute LD50 must be significantly in excess of this. Based on the low dermal absorption rate of the substance, (see chapter 7.1.2), acute toxicity by the dermal route would not be expected.

There is no acute studies by inhalation available for this substance. Taking into account the very low volatility and uses of this substance, along with the acute data from other routes, it can be concluded that there is no hazard from the inhalation of saturated vapour concentrations at ambient temperatures.

Based on observations from the lower members, higher molecular weight species in this homologous series of polyalkylene glycol methyl ethers will show decreasing potential for acute toxicity so these results can be considered representative of this substance.

Justification for classification or non-classification

Base on the available data, the substance clearly does not meet the criteria for classification for acute toxicity by any route of exposure.