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EC number: 245-883-5 | CAS number: 23783-42-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
ORAL - RATS (mg/kg)
TetraEGME LD50: 15000 mg/kg; LD0 5000mg/kg
Supporting information:
TEGME: LD50: >10500, 11.3ml/kg
Mix of tri, tetra and penta methyls: >5000mg/kg, 10760-13450 mg/kg. LD0: 5ml/kg, 5g/kg
DERMAL LD50 (mg/kg)
TEGME: Rabbit: 7100mg/kg
Rat: Mix of tri, tetra and penta methyls: Rat LD0: >2000mg/kg
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 10 500 mg/kg bw
Additional information
A number of LD50 studies are available in rats using the substances methyl triglycol and methyl tetraglycol. The key study selected shows that the LD50 exceeds 10500mg/kg.
Acute dermal toxicity data is available in both the rat and rabbit for tri and tetraethylene glycol methyl ether and formulations containing these substances. An LD50 of ~7.5mg/kg was established in the rabbit whilst a figure of >2000mg/kg was established in the rat from a recent GLP limit study using a mixture of primarily tri, tetra and penta ethylene glycol methyl ethers. In a sub-chronic dermal toxicity study using rats (reported in chapter 7.5.2) a NOAEL of 4000mg/kg was established, indicating that the acute LD50 must be significantly in excess of this. Based on the low dermal absorption rate of the substance, (see chapter 7.1.2), acute toxicity by the dermal route would not be expected.
There is no acute studies by inhalation available for this substance. Taking into account the very low volatility and uses of this substance, along with the acute data from other routes, it can be concluded that there is no hazard from the inhalation of saturated vapour concentrations at ambient temperatures.
Based on observations from the lower members, higher molecular weight species in this homologous series of polyalkylene glycol methyl ethers will show decreasing potential for acute toxicity so these results can be considered representative of this substance.
Justification for classification or non-classification
Base on the available data, the substance clearly does not meet the criteria for classification for acute toxicity by any route of exposure.
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