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EC number: 295-322-3 | CAS number: 91995-60-7
The model predicted a permeability coefficient of 0.0071 cm/hour.
Derivation of the initial dermal absorption
As is deduced in EHC 235 (2006), the following equation is true:
Kp= Km * D/h 
(Kpis the permeability coefficient; Kmis the pseudo-homogeneous partition, or distribution coefficient between the stratum corneum and the vehicle; D is the effective diffusion coefficient; h is the membrane thickness)
To derive the Kpfor the neat substance, the aqueous Kphas to be divided by the stratum corneum/water partition coefficient (Km). The Km(stratum corneum/water) for TAME was calculated to be 3.34 by using the QSAR described by ten Berge (2009).
Since the aqueous Kpwas 0.0071 cm/hour, the Kpfor neat liquid is: 0.0071 / 3.34 = 0.0021 cm/hour.
To derive the initial absorption of neat TAME, the Kpfor neat liquid has to be multiplied by the density. The density of TAME is 770 mg/cm3.
Therefore the initial absorption of neat TAME is 0.0021 cm/hour x 770 mg/cm3= 1.6 mg/cm2/hour
The above mentioned explanation can alternatively be expressed as follows:
Initial absorption (mg/cm2/hr) = rholiquid* (D/h) 
(rholiquidis the density of the liquid (mg/m3); D is the diffusion coefficient of the liquid in the stratum corneum (cm2/hr); h is the tickness of the stratum corneum)
D/h = Kp/Km 
(Kpis the permeability coefficient; Kmis the stratum corneum/water partition coefficient)
Substitution of equation 3 in 2 gives:
Initial absorption (mg/cm2/hr) = rholiquid* Kp/Km 
The density ofTAMEis770 mg/cm3; the Kpand Kmwere determined to be 0.0071 cm/hour and 3.34, respectively.
As such, the initial absorption (mg/cm2/hr) = 770 * 0.0071/3.34 = 1.6 mg/cm2/hour
In conclusion, the initial absorption of neat TAME is 1.6 mg/cm2/hour.
Correction for evaporation
Since TAME is very volatile, a strong competition between evaporation and skin absorption will occur in case the skin is exposed to neat TAME.
Based on the REACH Guidance appendix R14.1, it was calculated that the evaporation rate of TAME is 470 mg/cm2/hour.
Therefore, of each dose of TAME exposed to the skin 0.34% (1.6/470) is available for skin absorption because of the majority of the TAME evaporates before absorption can occur.
As such, the percentage of dermal absorption of TAME is assumed considered to be 0.34%. For the calculation of the dermal DNEL, a percentage of dermal absorption of 0.4% is used (which is worse-case).
EHC 235 Environmental Health Criteria 235: Dermal Absorption, World Health Organization 2006.
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