Registration Dossier

Ecotoxicological information

Long-term toxicity to fish

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

Data are available for MTBE. The 31-d NOEC for MTBE in the freshwater fish Pimephales promelas is 299 mg/l, a safety factor of 10 will be applied on this value. The outcome of this study is used to support the derivation of an effect concentration as a weighted average of the predicted values for the components of the substance.

Key value for chemical safety assessment

Additional information

Based on the considerations described in the document “Read-across substantiation C5-6 branched alkylmethyl-ethers” (incl. the supporting references Tuppurainen et al., 2007 and Niska et al., 2008), it can be concluded that the available information can be used to predict the long-term toxicity to fish of the substance ‘C5-6 branched alkylmethyl-ethers’ with sufficient certainty.

In order to take the indicated higher ecotoxicological potential of the other components of the C5-6 branched alkylmethyl-ethers (compared to the TAME) into account, a weighted average value was calculated:

Endpoint

Weighted average (mg/l)

Chronic toxicity to fish

11

The outcome of the following study is used to support the derivation of an effect concentration as a weighted average of the predicted values for the components of the substance (see attachments for details):

No chronic studies with fish are available for TAME, an ELS test with eggs and larvae/fry of fathead minnow (Pimephales promelas) is available for MTBE (ENSR, 1999). This result is used for read-across, the 31-d NOEC is 299 mg/l and a safety factor of 10 will be applied to this value in case of TAME.