Registration Dossier

Administrative data

Link to relevant study record(s)

Description of key information

A QSAR-derived permeability coefficient (Kp) for TAME was available. Furthermore, an experimentally derived Kp for MTBE, a highly similar substance, was available. The QSAR-derived Kp was 0.0071 cm/hour and the experimentally derived Kp of MTBE was 0.0035 cm/hour after correction for the higher temperature. For the calculation of the percentage absorption, the aqueous Kp of 0.0071 cm/hour was used.

Key value for chemical safety assessment

Absorption rate - dermal (%):
0.4

Additional information