Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 295-322-3 | CAS number: 91995-60-7
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Data are available for TAME and MTBE. The 96-h LC50 for TAME is 580 mg/l in the freshwater fish Onchorhynchus mykiss.
For marine fish the 96-h LC50 is 574 mg/l for MTBE found in Menidia beryllina. A safety factor of 10 will be applied on this value.
The outcome of these studies is used to support the derivation of an effect concentration as a weighted average of the predicted values for the components of the substance.
Key value for chemical safety assessment
Additional information
Based on the considerations described in the document “Read-across substantiation C5-6 branched alkylmethyl-ethers” (incl. the supporting references Tuppurainen et al., 2007 and Niska et al., 2008), it can be concluded that the available information can be used to predict the short-term toxicity to fish of the substance ‘C5-6 branched alkylmethyl-ethers’ with sufficient certainty.
In order to take the indicated higher ecotoxicological potential of the other components of the C5-6 branched alkylmethyl-ethers (compared to the TAME) into account, a weighted average value was calculated:
Endpoint |
Weighted average (mg/l) |
Acute toxicity to fish |
85 |
The outcome of the following studies is used to support the derivation of an effect concentration as a weighted average of the predicted values for the components of the substance (see attachments for details):
For fish, there are three guideline studies on TAME available. The studies are either semi-static or flow-through. The most critical study is therefore chosen as the key study. The lowest observed effect concentration is a 96-h LC50 value of 580 mg/l in Onchorhynchus mykiss (Springborn Laboratories Inc., 1994a). As no data is available for marine fish, the data from MTBE are used for read-across, the lowest effect concentration in marine fish for MTBE is a 96-h LC50 of 574 mg/l in inland silverside (Menidia beryllina) (BenKinney et al., 1994), applying a safety factor of 10 to this value results in an effect concentration of 57.4 mg/l for TAME.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
