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EC number: 295-322-3 | CAS number: 91995-60-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
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- Auto flammability
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- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
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- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
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- Nanomaterial aspect ratio / shape
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- Nanomaterial surface chemistry
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- Endpoint summary
- Stability
- Biodegradation
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- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
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- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
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- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP non-guideline study, published in peer reviewed literature
Data source
Reference
- Reference Type:
- publication
- Title:
- In vivo exposure of female rats to toxicanta may affect oocyte quality.
- Author:
- Berger T and Horner CM
- Year:
- 2 003
- Bibliographic source:
- Reprod. Toxicol. 17, 273-281
Materials and methods
- GLP compliance:
- not specified
- Type of method:
- in vivo
Test material
- Reference substance name:
- 2-methoxy-2-methylbutane
- EC Number:
- 213-611-4
- EC Name:
- 2-methoxy-2-methylbutane
- Cas Number:
- 994-05-8
- Molecular formula:
- C6H14O
- IUPAC Name:
- 1,1-dimethylpropyl methyl ether
Constituent 1
Results and discussion
Any other information on results incl. tables
The fertilisability of oocytes was investigated following a 2-week exposure to rats via drinking water to TAME. The preceding two weeks of the oocyte recovery, young female Sprague-Dawley rats (28-45 days) were treated with 0.3% TAME. Controls received drinking water only. The rats were induced to ovulate with gonadotropin. After treatment, the females were killed, oviducts were removed and the oocytes isolated and transferred to fertilisation medium. The Zona pellicuda was removed before insemination. Oocytes (in 100 μl) were inseminated with 10 μl of sperm diluted to either 7*10E6 or 0.5*10 E6 sperm/ml. Three replicates were inseminated with 7*10E6 sperm/ml and three replicates with 0.5*10 E6 sperm/ml. Following 20 hours of incubation at 37°C, oocytes were rinsed and transferred to cover slips for examination. TAME did not have an effect on the final weight of the females. The treatment did not have an effect on the oocytes fragility. However, the results showed that the fertilisability of the oocytes decreased after consumption of TAME. The percentage of fertilised oocytes was 84% in the control group and 64% in the one treated with TAME.
In vivo administered TAME seemed to have an inhibitory effect on the fertilisability of rat oocytes in vitro. However, this finding was not supported by the findings in the 2-generation reproductive toxicity study. Therefore, the significance of this observation fertility is left unknown.
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