Registration Dossier
Registration Dossier
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EC number: 295-322-3 | CAS number: 91995-60-7
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Data are available for TAME. The 72-h ErC50 is 780 mg/l and the 72-h NOEC is 77 mg/l in Pseudokirchneriella subcapitata.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 780 mg/L
- EC10 or NOEC for freshwater algae:
- 77 mg/L
Additional information
Based on the considerations described in the document “Read-across substantiation C5-6 branched alkylmethyl-ethers” (incl. the supporting references Tuppurainen et al., 2007 and Niska et al., 2008), it can be concluded that the available information of TAME can be used to predict the toxicity to aquatic algae and cyanobacteria of the substance ‘C5-6 branched alkylmethyl-ethers’ with sufficient certainty.
Several studies with TAME in algae are available; all are conducted according to accepted guidelines. One study was considered invalid as test concentrations could not be maintained and the cell concentration in the controls in all replicates was smaller after 72 hours than after 48 hours (Springborn Laboratories Inc., 1995). From the other studies the most critical study is chosen as the key study. The lowest 72-h ErC50 value is 780 mg/l and the 72-h NOEC is 77 mg/l (SafePharm Laboratories, 2003a). These values are used in the assessment since no data are available to support the derivation of a weighted average.
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