Registration Dossier
Registration Dossier
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EC number: 295-322-3 | CAS number: 91995-60-7
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Data are available for TAME and MTBE. For marine invertebrates the 28-d NOEC is 3.39 mg/l in Americamysis bahia for TAME.
The 21-d NOEC for MTBE in Daphnia magna is 51 mg/l, applying a safety factor of 10 results in an NOEC of 5.1 mg/l.
The outcome of these studies is used to support the derivation of an effect concentration as a weighted average of the predicted values for the components of the substance.
Key value for chemical safety assessment
Additional information
Based on the considerations described in the document “Read-across substantiation C5-6 branched alkylmethyl-ethers” (incl. the supporting references Tuppurainen et al., 2007 and Niska et al., 2008), it can be concluded that the available information can be usedto predict the long-term toxicity to aquatic invertebrates of the substance ‘C5-6 branched alkylmethyl-ethers’ with sufficient certainty.
In order to take the indicated higher ecotoxicological potential of the other components of the C5-6 branched alkylmethyl-ethers (compared to the TAME) into account, a weighted average value was calculated:
Endpoint |
Weighted average (mg/l) |
Chronic toxicity to daphnids |
4.4 |
The outcome of the following studies is used to support the derivation of an effect concentration as a weighted average of the predicted values for the components of the substance (see attachments for details):
One chronic test with TAME in marine invertebrates is available; the study is conducted according to accepted guidelines. The 28-d NOEC inAmericamysis bahiais 3.39 mg/l (T.R. Wilbury Laboratories, Inc., 2004). No chronic studies with freshwater invertebrates are available. A guideline study is available for MTBE withDaphnia magna, the 21-d NOEC is 51 mg/l (Wildlife International Ltd., 1999). A safety factor of 10 is applied to this value, resulting in an effect concentration of 5.1 mg/l for TAME.
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