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EC number: 206-466-3 | CAS number: 345-92-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2005-11-11 to 2005-12-30
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline comparable study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2005
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Bis(4-fluorophenyl) ketone
- EC Number:
- 206-466-3
- EC Name:
- Bis(4-fluorophenyl) ketone
- Cas Number:
- 345-92-6
- Molecular formula:
- C13H8F2O
- IUPAC Name:
- bis(4-fluorophenyl)methanone
- Reference substance name:
- 4,4'-Difluorobenzophenone
- IUPAC Name:
- 4,4'-Difluorobenzophenone
- Details on test material:
- bis(4-fluorophenyl) ketone,
purity: 99 %,
physical state: white powder,
storage conditions: test substance was stored in the refrigator of sample room and kept only in the original container
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ORGANISMS:
- Source: SINO-BRITISH SIPPR/BK LAB ANIMAL LTD in Shanghai
- Age at administration: 6 weeks
- Body weight at study initiation: 180 -200 g
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 7 days
- Temperature (°C): 20 °C +/- 2° C
- Humidity (%): 45 % - 65 %
- Air changes (per hr): 15 times
- Illumination: natural lights
- Cages: 32 x 32 x 50 cm
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- soya oil
- Details on dermal exposure:
- Animals were shaved on the back part about an area of 5 x 8 cm2. The animals were observed for 24 hours and animals without any injury for study were used. The dose volume was calculated from body weight just before adiminstration. Prescribed amount of the substance was mixed with soybean oil and was applied directly to the sheared area and smeared it evenly. Then the application sites were covered with one layer of plastic film and four layers of gauze. The gauze layers were fixed with adhesive tape tightly to the animals. Twenty-four hours after the application, the dressing was removed and the skin was flushed with lukewarm tap water.
- Duration of exposure:
- 24 hours
- Doses:
- one dose level: 2500 mg/kg bw
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
- Details on study design:
- The limit test at one dose level of 2500 mg/kg bw was carried out in a group of 5 males and 5 females using the procedures described above.
All animals were observed 30 minutes continuously after exposure, then hourly for 6 hours after treatment administration, and at least twice daily (forenoon and afternoon) thereafter. Clinical symptoms were recorded. The animals were observed for 14 days after treatment. Each animal was weighed on days 1, 7 and 14 during the observation period and in case of dead animals being found. At the end of the observation period, all survived animals were necropsied. - Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 500 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No deaths occurred.
- Mortality:
- No mortalities were observed.
- Clinical signs:
- other: No apparent abnormalities were found at 2500 mg/kg bw of both sexes.
- Gross pathology:
- no data
- Other findings:
- No apparent changes were found in necropsy
Any other information on results incl. tables
no further information
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- The LD50 value (dermal) of bis(4-fluorophenyl) ketone in male and female rats was estimated to be > 2500 mg/kg bw. No mortalities and no clinical signs were observed. Therefore, under the conditions of this study the acute toxicity of bis(4-fluorophenyl) ketone after dermal exposure is very low.
- Executive summary:
The acute dermal toxicity study of bis(4-fluorophenyl) ketone was conducted with one group of Sprague-Dawley rats for each sex. Each group consited of 5 rats. The male and female rats were treated with 2500 mg/kg bw. Animals were observed for symptoms of clinical toxicity and mortality for 14 days after treatment. No apparent changes were found in body weight and necropsy. Results are summarized as follows: Approximate LD50 male rat: > 2500 mg/kg bw, LD50 female rat: > 2500 mg/kg bw.
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