Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 206-466-3 | CAS number: 345-92-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Bis(4-fluorophenyl) ketone is of low dermal and inhalative acute toxicity with a dermal LD50 (rat) of > 2500 mg/kg bw (Qing_2006) and an inhalative LC50 (rat, aerosol, 4 hrs) of > 5050 mg/m3 (Zhang_2006). The LD50 value (oral) of bis(4-fluorophenyl) ketone in female and male rats was estimated to be 2000 mg/kg bw (Qing_2006). Therefore, under the conditions of the study the acute toxicity of the test substance after oral exposure in rats is moderate and bis(4-fluorophenyl) ketone has to be classified as harmful if swallowed.
Key value for chemical safety assessment
Additional information
Justification for classification or non-classification
Based on the results of the acute dermal and inhalation studies with bis(4 -fluorophenyl) ketone
and according to the criteria of CLP Regulation 1272/2008 no classification is required for acute dermal and inhalation toxicity. The oral LD50 value of bis(4-fluorophenyl) ketone in rats was estimated to be 2000 mg/kg bw. Thus the substance has to be classified for acute oral toxicity according CLP regulation 1272/2008, Category 4, H302: Harmful if swallowed.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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