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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Bis(4-fluorophenyl) ketone is of low dermal and inhalative acute toxicity with a dermal LD50 (rat) of > 2500 mg/kg bw (Qing_2006) and an inhalative LC50 (rat, aerosol, 4 hrs) of > 5050 mg/m3 (Zhang_2006). The LD50 value (oral) of bis(4-fluorophenyl) ketone in female and male rats was estimated to be 2000 mg/kg bw (Qing_2006). Therefore, under the conditions of the study the acute toxicity of the test substance after oral exposure in rats is moderate and bis(4-fluorophenyl) ketone has to be classified as harmful if swallowed.

Key value for chemical safety assessment

Additional information

Justification for classification or non-classification

Based on the results of the acute dermal and inhalation studies with bis(4 -fluorophenyl) ketone

and according to the criteria of CLP Regulation 1272/2008 no classification is required for acute dermal and inhalation toxicity. The oral LD50 value of bis(4-fluorophenyl) ketone in rats was estimated to be 2000 mg/kg bw. Thus the substance has to be classified for acute oral toxicity according CLP regulation 1272/2008, Category 4, H302: Harmful if swallowed.