Registration Dossier
Registration Dossier
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EC number: 471-480-0 | CAS number: 1645-83-6
Endpoint summary
Administrative data
Description of key information
Additional information
Abiotic degradation:
The test substance is degraded by its reaction with OH in the air in 2 weeks. Consequently it can be concluded that the substance will not persist in the atmosphere. The substance is expected to be hydrolytically stable as it contains no hydrolysable functionalities.
Biotic degradation:
The substance is not readily biodegradable according to an OECD TG 301D study. The substance is a gas at room temperature. In addition, it is likely to partition to the water rather than to the sediment and soil compartments as it has a relatively low partition coefficient (log Kow = 1.6) and adsorption coefficient (Koc = 71.1 L/kg). Furthermore, the high vapour pressure (427.1 kPa) and Henry’s law constant (8.7E+04 Pa*m3/mol) suggest that the substance will volatilize rapidly from water and partition to the air. With the current biodegradation status of the substance, the CSA indicates that the risks in the water, sediment and soil compartments are controlled and no further information will have to be provided. Based on all the information, the biodegradation simulation tests in water, sediment and soil are waived.
Bioaccumulation:
No bioaccumulation is expected in fish based on the log Kow of 1.6. Based on the physical state of the substance at room temperature (gaseous), the substance is not expected to be surface active or ionisable at environmental pH (pH 4-9). The BCF in aquatic organisms was estimated using the Veith relationship which is incorporated in EUSES: log BCF = 0.85·log Kow - 0.70 (applicable for substances with log Kow ≤6). This results in an estimated BCF for fish of 4.57 L/kg w.w.
Transport and distribution:
The substance can be expected to have a low potential for adsorption based on the log Kow of 1.6. The substance at room temperature is gaseous. The substance is not expected to be surface active or ionisable at environmental pH (pH 4-9). The organic carbon-water partitioning coefficient (Koc) was calculated from the log Kow using the equation from EUSES (non-hydrophobics QSAR): log Koc = 0.52·logKow + 1.02. The calculated Koc value is 71.1 L/kg (log Koc = 1.852). This predicted value is used in the assessment.
The Henry's law constant is calculated in EUSES using the substance's molecular weight of 114 g/mol, the experimentally determined vapour pressure of 427.1 kPa (at 20 °C) and the water solubility of 373 mg/L (at 24 °C). The Henry's law constant at environmental temperature (12 °C) is calculated to be 8.7E+04 Pa·m³/mol. Based on this value, the substance is expected to volatilise rapidly from water.
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