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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
Qualifier:
according to guideline
Guideline:
other: Method for testing partition coefficient by Japanese Ministry of Environment
GLP compliance:
yes
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
1.6
Temp.:
25 °C
pH:
7
Details on results:
All reference standards had measured log kow values that were expected
Conclusions:
The substance has a log Kow of 1.6.
Executive summary:

The partitioning coefficient octanol-water (Kow) of the substance was determined in a study in accordance with OECD TG 117 (HPLC method) and in compliance with GLP criteria (Kurume Laboratory, 2008). From the results, a log Kow of 1.6 was determined for the test substance.

Description of key information

A log Kow of 1.6 was determined for the test substance.

Key value for chemical safety assessment

Log Kow (Log Pow):
1.6
at the temperature of:
25 °C

Additional information

In the key study, the HPLC method was used to determine the Log Kow of 1.6. The supporting study presents an estimated log Kow  value of 2.01 according to KOWWIN 1.67.