1-Propene, 1,3,3,3-tetrafluoro-

Additional toxicological data

Administrative data

Endpoint:

additional toxicological information

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2006

Report date:

2006

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

Cardiac sensitisation was considered to have occurred if the response to epinephrine was enhanced following administration of the test article.

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

-

EC Number:

471-480-0

EC Name:

-

Cas Number:

1645-83-6

Molecular formula:

Hill formula: C3H2F4 CAS formula: C3H2F4

IUPAC Name:

(1E)-1,3,3,3-tetrafluoroprop-1-ene

Results and discussion

Any other information on results incl. tables

All animals survived to study termination. There were no test article-related clinical observations. Body weights were unaffected by test article administration.No cardiac sensitization observed in any animals

Applicant's summary and conclusion

Conclusions:

Cardiac sensitisation was to epinephrine was not observed in dogs exposed by inhalation to HFO-1234ze up to to a level of 120000 ppm (highest dose tested)