Registration Dossier

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Genetic toxicity in vitro

Description of key information

HFO-1234ze was not mutagenic in S. typhimurium strains TA100, TA1535, 1537, TA98 and E. coli WP-2 (with or without S9). It was found not to be clastogenic in cultured human lymphocytes.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (negative)

Genetic toxicity in vivo

Description of key information

HFO-1234ze was negative in the following threein vivogenotoxicity studies: micronucleus – mouse (acute inhalation exposure) and rats (4-week inhalation exposure) and UDS test (unscheduled DNA synthesis) following 4-week inhalation exposure.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (negative)

Additional information

Based on these results of this battery of in vitro and in vivo studies it is concluded that HFO-1234ze is not genotoxic.

Justification for classification or non-classification

HFO-1234ze was not shown to be genotoxic in in vitro or in vivo genotoxicity studies. No classification is deemed necessary.

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