Zirconium tetrapropanolate

Toxicity to reproduction

Administrative data

Endpoint:

screening for reproductive / developmental toxicity

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Comparison of Behavioral Teratogenic Effects of Ethanol an N-Propanol administered by Inhalation to Rats

Author:

Nelson B.K., Brightwell W.S., Burg J.R

Year:

1985

Bibliographic source:

Neurobehavioral Toxicology and Teratology, Vol. 7, 779-783

Reference 2

Reference Type:

publication

Title:

Behavioral Teratology Investigation of 1-Propanol Administered by Inhalation to Rats

Author:

Nelson B.K., Brightwell W.S., Taylor B.J., Khan A., Burg J.R., Krieg E.F., Massari V.J.

Year:

1989

Bibliographic source:

Neurotoxicol.Teratol. 11, 153-159

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: other

Principles of method if other than guideline:

Male animals were treated for 42 days, then mated with untreated virgin females . Resulting pregnant females were sham exposed on gestation days 1-19 (experiment 1). Another group of untreated males and females were mated. Resulting pregnant females were then exposed to the test substance on gestation days 1-19 (experiment 2).

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Propan-1-ol

EC Number:

200-746-9

EC Name:

Propan-1-ol

Cas Number:

71-23-8

Molecular formula:

C3H8O

IUPAC Name:

Propan-1-ol

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Administration / exposure

Route of administration:

inhalation

Type of inhalation exposure (if applicable):

whole body

Vehicle:

air

Duration of treatment / exposure:

Experiment 1
- Males : 6 weeks premating
- Females: sham exposed


Experiment 2
- Males: sham exposed
- Females: day 1-19 of gestation

Frequency of treatment:

7 h/day. 7 days/week.

Doses / concentrations

Doses / concentrations 1

Dose / conc.:

0 mg/m³ air (nominal)

Doses / concentrations 2

Dose / conc.:

8 730 mg/m³ air (nominal)

Doses / concentrations 3

Dose / conc.:

17 460 mg/m³ air (nominal)

Doses / concentrations 4

Dose / conc.:

24 940 mg/m³ air (nominal)

No. of animals per sex per dose:

female 15; male 18

Results and discussion

Results: P0 (first parental generation)

Reproductive function / performance (P0)

Reproductive function: oestrous cycle:

no effects observed

Effect levels (P0)

Key result

Dose descriptor:

NOAEC

Effect level:

ca. 8 730 mg/m³ air (nominal)

Based on:

test mat.

Sex:

male

Basis for effect level:

other: Based on the reversible fertility effects

Results: F1 generation

Effect levels (F1)

Key result

Dose descriptor:

NOAEC

Generation:

F1

Effect level:

ca. 3 500 ppm (nominal)

Based on:

test mat.

Sex:

male/female

Basis for effect level:

clinical signs

Overall reproductive toxicity

Key result

Reproductive effects observed:

no

Lowest effective dose / conc.:

8 730 mg/m³ air

Treatment related:

no