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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Data source

Reference
Reference Type:
publication
Title:
Comparative Effects of Ethanol , n-Propanol add Isopropanol on Lipid Disposal by Rat Liver
Author:
Beaugé F., Clement M., Nordmann J., Nordmann r
Year:
1979
Bibliographic source:
Chem.-Biol. Interactions, 26, 155-166

Materials and methods

Objective of study:
absorption
metabolism
Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 417 (Toxicokinetics)
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Propan-1-ol
EC Number:
200-746-9
EC Name:
Propan-1-ol
Cas Number:
71-23-8
Molecular formula:
C3H8O
IUPAC Name:
Propan-1-ol
Radiolabelling:
yes
Remarks:
C14

Test animals

Species:
rat
Strain:
Wistar
Sex:
female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Doses / concentrations
Dose / conc.:
3 005 mg/kg bw/day (nominal)
No. of animals per sex per dose / concentration:
3

Results and discussion

Toxicokinetic / pharmacokinetic studies

Details on absorption:
The propan-1-ol concentration in blood serum peaked one hour after administration. a peak blood level of approximately 1800 mg/l after about 1.5 hours could be derived. Thereafter blood levels decreased rapidly to below detection limits (5 h after dosing)

The rate of metabolism of n-propanol was 510 mg (8.5 mmol)/kg/h.

Applicant's summary and conclusion