Zirconium tetrapropanolate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Justification for type of information:

1-propanol is the main hydrolysis prodcuts of the target substance. Properties of the the hydrolysis substance are used for read-across.

Data source

Reference

Reference Type:

publication

Title:

A Comparison of the Toxicity of Some Allyl, Propenyl, and Propyl Compounds in the Rat.

Author:

Taylor J.M., Jenner P.M., Jones W.I.

Year:

1964

Bibliographic source:

Toxicol. Appl. Pharmacol. 6, 378-387.

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: other

Principles of method if other than guideline:

Group of 5 male and 5 female rats (180-350 g) per dose level were administered the test substance by stomach tube. The rats were fasted 18 hr before administration. The rats were observed until the survivors had returned to normal in appearance and weight.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Propan-1-ol

EC Number:

200-746-9

EC Name:

Propan-1-ol

Cas Number:

71-23-8

Molecular formula:

C3H8O

IUPAC Name:

Propan-1-ol

Test animals

Species:

rat

Strain:

Osborne-Mendel

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

No. of animals per sex per dose:

5

Control animals:

no

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

ca. 6 500 mg/kg bw

Based on:

test mat.

Mortality:

Mortality occured within 2 - 18 hr after administration.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The oral LD50 on rats was 6500 mg/kg bw. GHS criteria was not met for acute oral toxicity.

Executive summary:

As the target substance hydrolyses rapidly (half-life < 5 minutes) the intrinsic properties are related to hydrolysis products of the target substance. This information is used as a supporting evidence on the toxicity of the target substance in CSA.