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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Justification for type of information:
1-propanol is the main hydrolysis prodcuts of the target substance. Properties of the the hydrolysis substance are used for read-across.

Data source

Reference
Reference Type:
publication
Title:
A Comparison of the Toxicity of Some Allyl, Propenyl, and Propyl Compounds in the Rat.
Author:
Taylor J.M., Jenner P.M., Jones W.I.
Year:
1964
Bibliographic source:
Toxicol. Appl. Pharmacol. 6, 378-387.

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: other
Principles of method if other than guideline:
Group of 5 male and 5 female rats (180-350 g) per dose level were administered the test substance by stomach tube. The rats were fasted 18 hr before administration. The rats were observed until the survivors had returned to normal in appearance and weight.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
Osborne-Mendel
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
No. of animals per sex per dose:
5
Control animals:
no

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
ca. 6 500 mg/kg bw
Based on:
test mat.
Mortality:
Mortality occured within 2 - 18 hr after administration.
Body weight:
Weight loss observed.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The oral LD50 on rats was 6500 mg/kg bw. GHS criteria was not met for acute oral toxicity.
Executive summary:

As the target substance hydrolyses rapidly (half-life < 5 minutes) the intrinsic properties are related to hydrolysis products of the target substance. This information is used as a supporting evidence on the toxicity of the target substance in CSA.