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Toxicological information

Repeated dose toxicity: inhalation

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Administrative data

Endpoint:
short-term repeated dose toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Remarks:
authority reviewed.

Data source

Reference
Reference Type:
secondary source
Title:
EU Risk Assessment Report, CAS No. 71-23-8: Propan-1-ol, Vol. 82
Author:
European Chemicals Bureau
Year:
2008
Bibliographic source:
EU Risk Assessment Report
Report Date:
2008

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 412 (Subacute Inhalation Toxicity: 28-Day Study)
Principles of method if other than guideline:
Study followed intent of OECD 412 with only 9 exposures in 12 days.
GLP compliance:
not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
air
Details on inhalation exposure:
6 hr/day, 4 days/week up to 2 weeks. (9 exposure days)
Doses / concentrationsopen allclose all
Dose / conc.:
246 mg/m³ air
Dose / conc.:
1 230 mg/m³ air
Dose / conc.:
2 460 mg/m³ air

Results and discussion

Results of examinations

Clinical signs:
effects observed, treatment-related
Description (incidence and severity):
slightly swollen periocular tissue, and minimal perinasal and periocular encrustations in the 1000 ppm (2460 mg/m3) exposure concentration group

Effect levels

Key result
Dose descriptor:
NOAEC
Effect level:
ca. 1 230 mg/m³ air
Based on:
test mat.
Sex:
male/female
Basis for effect level:
clinical signs

Applicant's summary and conclusion