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Toxicological information

Repeated dose toxicity: oral

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Administrative data

Endpoint:
chronic toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Effects of chronic ingestion of some lower aliphatic alcohols in rats.
Author:
Hillbom, ME; Franssila, K; Forsander, OA
Year:
1974
Bibliographic source:
Res Commun Chem Pathol Pharmacol. 1974 Sep;9(1):177-80
Reference Type:
secondary source
Title:
EU Risk Assessment Report, CAS No. 71-23-8: Propan-1-ol, Vol. 82
Author:
European Chemicals Bureau
Year:
2008
Bibliographic source:
EU Risk Assessment Report
Report Date:
2008

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: other
Principles of method if other than guideline:
single dose
GLP compliance:
not specified
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
not specified
Sex:
male

Administration / exposure

Route of administration:
oral: drinking water
Vehicle:
water
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
4 months

Results and discussion

Results of examinations

Clinical signs:
no effects observed
Mortality:
no mortality observed
Body weight and weight changes:
no effects observed
Food consumption and compound intake (if feeding study):
no effects observed

Effect levels

Key result
Dose descriptor:
NOAEL
Effect level:
ca. 3 000 mg/kg bw/day (nominal)
Based on:
test mat.
Sex:
male
Basis for effect level:
clinical signs

Target system / organ toxicity

Key result
Critical effects observed:
no

Applicant's summary and conclusion