Registration Dossier
Registration Dossier
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EC number: 701-219-0 | CAS number: 15174-47-7
Toxicity to reproduction
Administrative data
- Endpoint:
- reproductive toxicity, other
- Remarks:
- QSAR
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- 2012
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Version / remarks:
- QSAR determination
- Principles of method if other than guideline:
- The evaluation of the potential toxicity of the alpha-methyl cinnamic aldehyde (CAS # 101-39-3), performed using a QSAR analysis by means of Derek Nexus 2.0.3
- GLP compliance:
- no
- Remarks:
- QSAR
Test material
- Reference substance name:
- (E)-2-methyl-3-phenylprop-2-enal
- Cas Number:
- 15174-47-7
- IUPAC Name:
- (E)-2-methyl-3-phenylprop-2-enal
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Test material was described with the generic name "alpha-methyl cinnamic aldehyde", using generic CAS 101-39-3. The structure used in the QSAR analysis (shown in Appendix A) is the trans-isomer, which is consistent with CAS 15174-47-7.
Results and discussion
Results: P0 (first parental generation)
Effect levels (P0)
- Key result
- Dose descriptor:
- other: Structural alerts for reproductive and/or developmental toxicity
- Effect level:
- other:
- Remarks on result:
- not measured/tested
- Remarks:
- No structural alerts found for reproductive and/or developmental toxicity
Results: F1 generation
Effect levels (F1)
- Key result
- Dose descriptor:
- other: Structural alerts for reproductive and/or developmental toxicity
- Sex:
- not specified
- Remarks on result:
- not measured/tested
- Remarks:
- No structural alerts found for reproductive and/or developmental toxicity
Overall reproductive toxicity
- Key result
- Reproductive effects observed:
- no
Any other information on results incl. tables
No structural alerts found for reproductive and/or developmental toxicity
Applicant's summary and conclusion
- Conclusions:
- No structural alerts found for reproductive and/or developmental toxicity
- Executive summary:
No structural alerts found for reproductive and/or developmental toxicity.
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