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Toxicological information

Toxicity to reproduction

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Administrative data

Endpoint:
reproductive toxicity, other
Remarks:
QSAR
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Study period:
2012
Reliability:
2 (reliable with restrictions)
Justification for type of information:
QSAR prediction

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
2012
Report date:
2012

Materials and methods

Test guideline
Qualifier:
no guideline required
Version / remarks:
QSAR determination
Principles of method if other than guideline:
The evaluation of the potential toxicity of the alpha-methyl cinnamic aldehyde (CAS # 101-39-3), performed using a QSAR analysis by means of Derek Nexus 2.0.3
GLP compliance:
no
Remarks:
QSAR

Test material

Constituent 1
Chemical structure
Reference substance name:
(E)-2-methyl-3-phenylprop-2-enal
Cas Number:
15174-47-7
IUPAC Name:
(E)-2-methyl-3-phenylprop-2-enal
Test material form:
liquid
Specific details on test material used for the study:
Test material was described with the generic name "alpha-methyl cinnamic aldehyde", using generic CAS 101-39-3. The structure used in the QSAR analysis (shown in Appendix A) is the trans-isomer, which is consistent with CAS 15174-47-7.

Results and discussion

Results: P0 (first parental generation)

Effect levels (P0)

Key result
Dose descriptor:
other: Structural alerts for reproductive and/or developmental toxicity
Effect level:
other:
Remarks on result:
not measured/tested
Remarks:
No structural alerts found for reproductive and/or developmental toxicity

Results: F1 generation

Effect levels (F1)

Key result
Dose descriptor:
other: Structural alerts for reproductive and/or developmental toxicity
Sex:
not specified
Remarks on result:
not measured/tested
Remarks:
No structural alerts found for reproductive and/or developmental toxicity

Overall reproductive toxicity

Key result
Reproductive effects observed:
no

Any other information on results incl. tables

No structural alerts found for reproductive and/or developmental toxicity

Applicant's summary and conclusion

Conclusions:
No structural alerts found for reproductive and/or developmental toxicity
Executive summary:

No structural alerts found for reproductive and/or developmental toxicity.

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