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EC number: 701-219-0 | CAS number: 15174-47-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No guideline or method detailed in report.
- GLP compliance:
- no
- Remarks:
- Pre-GLP study.
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
- Reference substance name:
- (E)-2-methyl-3-phenylprop-2-enal
- Cas Number:
- 15174-47-7
- IUPAC Name:
- (E)-2-methyl-3-phenylprop-2-enal
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Test material was described with the generic name "alpha-methylcinnamaldehyde". As manufactured by Innospec, the product met the criteria of > 80% trans-isomer, supporting that the test material was the isomer better described as CAS 15174-47-7.
Compound No.: RIFM 72-257
Clear liquid
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- Not specified
- Duration of exposure:
- Not specified
- Doses:
- 5 gm/Kg bw
- No. of animals per sex per dose:
- 10 animals
- Control animals:
- not specified
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality was observed at 5000 mg/Kg bw
Any other information on results incl. tables
Table 1. Distribution of Mortality |
|||||||||||||||
Dose (g/Kg) |
Observation Day |
Mortality |
|||||||||||||
1 |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
9 |
10 |
11 |
12 |
13 |
14 |
||
5.0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0/10 |
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Remarks:
- Regulation (EC) No 1272/2008 on classification, labelling and packaging (CLP) of substances and mixtures
- Conclusions:
- The acute dermal LD50 of Alpha methyl cinnamic aldehyde was determined to be >5000 mg/Kg.
- Executive summary:
In a key acute dermal toxicity study, the test material (Alpha methyl cinnamic aldehyde) was dermally administered to rabbits (10/dose) at a dose of 5000 mg/kg (5 g/kg).
No mortality was observed through the study period.
The acute dermal LD50 of Alpha methyl cinnamic aldehyde was therefore determined to be >5000 mg/kg.
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