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EC number: 701-219-0
CAS number: 15174-47-7
A publication briefly describes an in
vivo micronucleus test carried out on groups of mice, conducted
using a protocol similar to OECD Guideline 474.
Groups of four mice were given two
intraperitoneal injections (at 0 and 24 hours) of α-methylcinnamaldehyde
at 146, 292 or 438 mg/kg bw/day. Six hours after the final injection,
mice were killed, and bone-marrow smears were prepared. Following
fixation and staining, 1000 polychromatic erythrocytes were analysed
from each animal, and the number of micronucleated polychromatic
erythrocytes was recorded.
Treatment with α-methylcinnamaldehyde
did not significantly induce increased numbers of micronuclei. Under the
conditions of this assay, no convincing evidence of mutagenic activity
was demonstrated for α-methylcinnamaldehyde.
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