α-d-Glucopyranoside, β-d-fructofuranosyl, benzoate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1974

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study without detailed documentation

Justification for type of information:

xxxx
See attached document in section 13

Data source

Reference

Reference Type:

other: SISD Assessment report

Title:

Unnamed

Year:

2001

Report date:

2001

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

EPA OTS 798.1150 (Acute inhalation toxicity)

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Benzoic acid

EC Number:

200-618-2

EC Name:

Benzoic acid

Cas Number:

65-85-0

Molecular formula:

C7H6O2

IUPAC Name:

benzoic acid

Test material form:

not specified

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

Ten rats (4 units of 2 or 3 rats/unit to prevent piling) were placed in a sealed 59.1 liter glass chamber and exposed to a dynamic atmosphere containing the dust of the test material. A Wright Dust Feeder controlled addition of the test substance; airflow regulated by a flowmeter. The rats were observed continuously during the 4-hour exposure, and for a period of 14 days following exposure.

Administration / exposure

Route of administration:

inhalation: dust

Type of inhalation exposure:

whole body

Vehicle:

air

Details on inhalation exposure:

The rats were placed in a sealed 59.1 liter glass chamber and exposed to a dynamic atmosphere containing the dust of the test material. A Wright Dust Feeder controlled addition of The test substance; airflow regulated by a flowmeter.

Duration of exposure:

4 h

No. of animals per sex per dose:

10 rats (2-3 rats per unit)

Control animals:

not specified

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LC50

Effect level:

12.2 mg/L air

Exp. duration:

4 h

Mortality:

All rats survived the 4-hour exposure and the 14-day observation period.

Clinical signs:

other: Signs during the exposure period included occasional increased motor activity and slight erythema. At the conclusion of exposure, 1 rat exhibited salivation.

Body weight:

At 24 hours and through the 14-day observation period, all rats appeared normal and exhibited normal body weight gains.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Executive summary:

Ten rats (4 units of 2 or 3 rats/unit to prevent piling) were placed in a sealed 59.1 liter glass chamber and exposed to a dynamic atmosphere containing the dust of the benzoic acid by Wright Dust Feeder controlled system and airflow regulated by a flowmeter. The rats were observed continuously during the 4-hour exposure, and for a period of 14 days following exposure. All of the rats survived the 4-hour exposure and the 14-day observation period. Signs during the exposure period included occasional increased motor activity and slight erythema. At the conclusion of exposure, 1 rat exhibited salivation. At 24 hours and through the 14-day observation period, all rats appeared normal and exhibited normal body weight gains.