Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:
short-term toxicity to aquatic invertebrates
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because the substance is unlikely to cross biological membranes, hence indicating that aquatic toxicity is unlikely to occur

Data source

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
α-d-Glucopyranoside, β-d-fructofuranosyl, benzoate
EC Number:
235-795-5
EC Name:
α-d-Glucopyranoside, β-d-fructofuranosyl, benzoate
Cas Number:
12738-64-6
Molecular formula:
C12-H22-O11.x-C7-H6-O2; x=5-8
IUPAC Name:
α-d-Glucopyranoside, β-d-fructofuranosyl, benzoate

Results and discussion

Applicant's summary and conclusion

Conclusions:
The QSAR (ECOSAR) estimated aquatic toxicity lies far above the estimated and measured water solubility. Furthermore the substance has a high molecular weight and cannot cross biological membranes. It is therefore concluded that the substance will not be acutely toxic to invertebrates at and below the water solubility.
Executive summary:

he water solubility of Sucrose benzoate was determined by flask method according to OECD test guideline 105.  The water solubility of Sucrose benzoate was determined after four days to be 3 mg/L at 20 °C. The water solubility is dependent on the numbers of benzoate groups attached to the molecule. A molecule with a low number of benzoate groups (1 -2) will have a higher solubility compared to a molecule with a higher number (7 -8) of benzoate groups attached.

The study which was conducted according to OECD guideline 105 is believed to have been conducted with sucrose benzoate with a variant number of benzoate groups attached.

The QSAR calculation for toxicity was conducted for a high number of groups attached (8)

QSAR was calculated based on smiles notation

SMILES : c0ccc(cc0)C(=O)OCC2C(C(C(C(O2)OC3(C(C(C(O3)COC(=O)c4ccccc4)OC(=O)c5ccccc5)OC(=O)c6ccccc6)COC(=O)c7ccccc7)OC(=O)c8ccccc8)OC(=O)c9ccccc9)OC(=O)c1ccccc1

The QSAR (ECOSAR) estimated aquatic toxicity lies far above the estimated and measured water solubility. Furthermore the substance has a high molecular weight and cannot cross biological membranes. It is therefore concluded that the substance will not be acutely toxic to invertebrates at and below water solubility.