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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
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- Nanomaterial pour density
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- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No OECD guideline or GLP defined.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 987
Materials and methods
- Objective of study:
- toxicokinetics
- Principles of method if other than guideline:
- effects of i.p. injection on toxicokinetics in rats
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Reaction mass of 3-methylphenyl diphenyl phosphate, 4-methylphenyl diphenyl phosphate, bis(3-methylphenyl) phenyl phosphate, 3-methylphenyl 4-methylphenyl phenyl phosphate and triphenyl phosphate
- Molecular formula:
- 3-methylphenyl diphenyl phosphate: C19H17O4P 4-methylphenyl diphenyl phosphate´: C19H17O4P triphenyl phosphate: C18H15O4P bis(3-methylphenyl) phenyl phosphate: C20H19O4P 3-methylphenyl 4-methylphenyl phenyl phosphate: C20H19O4P
- IUPAC Name:
- Reaction mass of 3-methylphenyl diphenyl phosphate, 4-methylphenyl diphenyl phosphate, bis(3-methylphenyl) phenyl phosphate, 3-methylphenyl 4-methylphenyl phenyl phosphate and triphenyl phosphate
- Details on test material:
- A commercial cresyl diphenyl phosphate preparation was analysed to contain approximately 35% of triphenyl phosphate, 45% of cresyl diphenyl phosphates, 18% of dicresyl phenyl phosphates and 2% of tricresyl phosphates.
Constituent 1
- Radiolabelling:
- not specified
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- olive oil
- Duration and frequency of treatment / exposure:
- single injection i.p.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
75, 150 or 300 mg/kg
- No. of animals per sex per dose / concentration:
- 5
- Control animals:
- not specified
Results and discussion
- Preliminary studies:
- no data
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- no data
- Details on distribution in tissues:
- 4 hours after the intraperitoneal injection of 300 mg test substance the Diphenyl-cresyl-phosphate level in blood was 0.3 +/- 0.2 µg/g. After 24 hours the level was below the detection limit (0.2 µg/g). In the liver the concentrations after 4 hours were 45.8 +/- 28.1 µg/g tissue and after 24 h 1.7 +/- 2.5 µg/g.
- Details on excretion:
- no data
Toxicokinetic parameters
- Toxicokinetic parameters:
- other: 4 h after the i.p. injection of 300 mg test subst. the DPK level in blood was 0.3 +/- 0.2 µg/g. After 24 h the level was below the detection limit (0.2 µg/g). In liver the conc. after 4 hours were 45.8 +/- 28.1 µg/g tissue and after 24 h 1.7 +/- 2.5 µg/g.
Metabolite characterisation studies
- Metabolites identified:
- not specified
Any other information on results incl. tables
Concentrations of Triarylphosphates in rat liver and blood 4 and 24 h after intraperitoneal injektion (300 mg/kg) of commercial cresyl diphenyl phosphate:
The concentrations are in µg/g wet tissue (mean of 5 animals +/- S.D.). The detection limit is 0.2 µg/g).
Time after treatment | TPP | CDPP | DCPP | TCP |
Liver | ||||
4h | 36.6 +/- 23.3 | 45.8 +/- 28.1 | 24.0 +/- 15.8 | 3.5 +/-2.8 |
24 h | 1.8 +/- 1.9 | 1.7 +/- 2.5 | 1.4 +/- 1.1 | < 0.2 |
Blood | ||||
4h | 0.7 +/- 0.3 | 0.3 +/- 0.2 | < 0.2 | < 0.2 |
No detectable amounts were found in blood 24 h after injection. |
TCP- tricresyl phosphates.
TPP-triphenyl phosphate
CDPP- cresyl diphenyl phosphates DCPP- dicresyl phenyl phosphates TCP- tricresyl phosphates.
Applicant's summary and conclusion
- Executive summary:
In a toxicokinetic study male Wistar rats (250 -300g) were injected intraperitoneally with 75, 150 or 300 mg/kg of a commercial triaryl phosphate preparation (Disflamoll DPK/25E, Bayer AG, F.R.G.) which was analysed to contain approximately 35% of triphenyl phosphate, 45% of cresyl diphenyl phosphates, 18% of dicresyl phenyl phosphates and 2% of tricresyl phosphates, in olive oil. The animals were decapitated 4h, 24 h, 1 week or 2 weeks after the injections and their brain, blood, liver, kidneys, glutea muscle and tail nerve samples were taken at autopsy.
4 hours after the intraperitoneal injection of 300 mg test substance the Diphenyl-cresyl-phosphate level in blood was 0.3 +/- 0.2 µg/g. After 24 hours the level was below the detection limit (0.2 µg/g). In the liver the concentrations after 4 hours were 45.8 +/- 28.1 µg/g tissue and after 24 h 1.7 +/- 2.5 µg/g.
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