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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No OECD guideline or GLP defined.
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976
Report date:
1976

Materials and methods

Principles of method if other than guideline:
Acute toxicity: intraperitoneal; neurotoxicity
GLP compliance:
not specified
Limit test:
no

Test material

Constituent 1
Reference substance name:
Not applicable
Molecular formula:
C19 H17 O4 P1
IUPAC Name:
Not applicable

Test animals

Species:
hen
Strain:
other: Leghorn
Sex:
female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
unchanged (no vehicle)
Doses:
2,5; 5 ml/kg bw.
No. of animals per sex per dose:
5/sex/dose
Control animals:
not specified

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
> 5 000

Any other information on results incl. tables

 Dose (ml/lg  Neurotoxicological result
 2,5  0/4
 5  3/4*

* = 2 animals killed earlier because of strong paresis (week 5)

Applicant's summary and conclusion

Conclusions:
The LD 50 was >5000 ml/kg bw (i.p., hen).
Executive summary:

DPK was administered i.p. to hens. A clear neurotoxic effect was shown at a dose of 5 ml/kg bw.

The LD 50 was >5000 ml/kg bw.