Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
One GLP compliant study is available for Disflamoll DPK (Weyers, 2006),
the 72-hour ErC50 (growth) was calculated to be 0.55 mg/L. The 72- hour EbC50 (biomass) was calculated to be 0.27 mg/L. Corresponding NOEC values were 0.11 and 0.022 mg/L, respectively. Two other studies have been reported using diphenyl cresyl phosphate as the test material, (Ueda et al, 1991 and Wong and Chau, 1984). The Ueda et al study gave a 72 hour EC50was determined to be 0.99 mg/L and the corresponding NOEC was 0.55 mg/L whilst the Wong and Chau study provided 4 hour medium inhibition concentrations (IC50) values were determined to be 0.7 mg/L for A. falcatus, 1.0 mg/L for S. quadricauda and 0.5 mg/L for Lake Ontario phytoplankton.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 0.55 mg/L
- EC10 or NOEC for freshwater algae:
- 0.11 mg/L
Additional information
A 72 hour algal inhibition study, according to EU method C.3, with Disflamoll DPK has been reported (Weyers, 2006). The 72-hour ErC50 (growth) was calculated to be 0.55 mg/L. The 72- hour EbC50 (biomass) was calculated to be 0.27 mg/L. Corresponding NOEC values were 0.11 and 0.022 mg/L, respectively.
A 72 hour algal inhibition study, according to OECD 201, was conducted with diphenyl cresyl phosphate (Ueda et al, 1991). The 72 hour EC50was determined to be 0.99 mg/L and the corresponding NOEC was 0.55 mg/L.
Primary productivity of tolyl diphenyl phosphate was measured in a series of non-standard studies with pure algal cultures of Scenedesmus quadricauda and Ankistrodesmus falcatus and natural phtyoplankton from Lake Ontario (Wong and Chau, 1984). The 4 hour medium inhibition concentrations (IC50) values were determined to be 0.7 mg/L for A. falcatus, 1.0 mg/L for S. quadricauda and 0.5 mg/L for Lake Ontario phytoplankton.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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