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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
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- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
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- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
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- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
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- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
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- Specific investigations
- Exposure related observations in humans
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- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
The acute oral toxicity of technical diphenyl cresyl phosphate based on
reliable acute toxicity studies is low.
In an acute oral toxicity test in 10 male and female Wistar rats the
LD50 was greater than 5000 mg/kg bw. The decrease of general condition
was the only symptom that could be seen (Loeser, 1982).
Acute toxicological investigations of male and female Wistar rats were
conducted after dermal exposure of diphenyl cresyl phosphate (Disflamoll
DPK). After administration of 2000 mg/kg bw no local signs and no
clinical signs were observed; also the body weight development of male
and female rats was not affected. No animal died and the animals
sacrificed at the end of study showed no noticeable gross pathological
findings. The LD50 was estimated to be greater than 2000 mg/ kg and was
not exactly determined (Krötlinger, 1999).
Additional studies are discussed by MAK 2003 or BG Chemie 2000 (no.
195). Overall the available data are consistent with the key studies,
indicating that the test substance has low acute toxicity.
There are no data on acute inhalation toxicity available.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Principles of method if other than guideline:
- Five male and five female rats received a single dose of 3.1 or 5 ml Disflamoll DPK/kg bw by gavage. The animals were observed for mortality, clinical signs, and body weight. A gross pathological examination of the surviving rats was conducted randomly.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Animals were housed in groups of 5 animals conventional in Macrolon cages type III on dust free wood granules at a temperature of 22+/- 1.5°C. Light/dark rythmus was 12 hours. and air humidity 60 +/- 55
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 5.0 ml/kg; 3.1 ml/kg bw.
- No. of animals per sex per dose:
- 5/sex/dose
- Control animals:
- not specified
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mL/kg bw
- Mortality:
- 1 male animal died at a dose of 5 ml/kg bw.
- Clinical signs:
- other: Decreased general condition.
- Gross pathology:
- No findings.
- Interpretation of results:
- GHS criteria not met
- Executive summary:
In an acute oral toxicity test in 10 male and female Wistar rats the LD50 was >5000 ml/kg bw (5000 ml/kg bw = 6050 mg/kg bw; density = 1.21 mg/µg).
The decrease of general condition was the only symptom that was seen.
Reference
Dose (ml/kg bw) | Sex | Mortality | No of animals | Animals with symtoms | start of symtoms | decrease of general condition | |
5,0 | male | 1 | 5 | 5 | after 10 hours | yes | |
5,0 | female | 0 | 5 | 5 | after 10 hours | yes |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- Scientifically acceptable and sufficient documented for evaluation.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- the number of animals and the procedure of dose finding were done with reference to OECD Guideline 423 due to animal welfare reasons.
- Principles of method if other than guideline:
- Three male and three female rats received a single dermal dose of 2000 mg Disflamoll DPK/kg bw. The animals were observed for mortality, clinical signs, and body weight during a 14 day period. A gross pathological examination was done on all animals at the end of the study.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- The mean initial weight of males was 268 g and of females 213 g.
- Type of coverage:
- other: non irritant skin plaster
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 3/sex/dose
- Control animals:
- not required
- Key result
- Sex:
- male/female
- Dose descriptor:
- discriminating dose
- Effect level:
- 2 000 mg/kg bw
- Mortality:
- no
- Clinical signs:
- other: no
- Gross pathology:
- no noticeable findings
- Other findings:
- no data
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 was estimated to be greater than 2000 mg/kg and was not exactly determined.
- Executive summary:
Acute toxicological investigations of male and female Wistar rats were conducted after dermal exposure of Diphenylkresylphosphate (Disflamoll DPK). After administration of 2000 mg/kg bw no local signs and no clinical signs were observed; also the body weight development of male and female rats was not affected.
No animal died and the animals sacrificed at the end of study showed no noticeable gross pathological findings.
The LD50 was estimated to be greater than 2000 mg/kg and was not exactly determined.
Reference
After administration of 2000 mg/kg bw no local signs and no clinical signs were observed; also the body weight development of male and female rats was not affected. No animal died and the animals sacrificed at the end of study showed no noticeable gross pathological findings. The LD50 was estimated to be greater than 2000 mg/ kg and was not exactly determined.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- Guideline study.
Additional information
Justification for classification or non-classification
The acute oral toxicity in rats is > 5000 mg/kg bw and the acute dermal toxicity in rats is > 2000 mg/kg bw. No reliable acute toxicity study by the inhalation route is available.
According to CLP classification criteria (Regulation (EC) No 1272/2008) a classification is not justified.
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