Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: No OECD guideline or GLP defined. Insufficient data documentation.
Data source
Reference
- Reference Type:
- publication
- Title:
- Studies on the toxicity and skin effects of compounds used in the rubber and plastics industries
- Author:
- Mallette F.S., von Haam E.
- Year:
- 1 952
- Bibliographic source:
- Arch. Hyg. Occup. Med. 6, 231-236 (1952)
Materials and methods
- Type of study / information:
- Skin irritation/corrosion in human
- Endpoint addressed:
- skin irritation / corrosion
- Principles of method if other than guideline:
- Skin irritation/corrosion in human (Patch test)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Reaction mass of 3-methylphenyl diphenyl phosphate, 4-methylphenyl diphenyl phosphate, bis(3-methylphenyl) phenyl phosphate, 3-methylphenyl 4-methylphenyl phenyl phosphate and triphenyl phosphate
- Molecular formula:
- 3-methylphenyl diphenyl phosphate: C19H17O4P 4-methylphenyl diphenyl phosphate´: C19H17O4P triphenyl phosphate: C18H15O4P bis(3-methylphenyl) phenyl phosphate: C20H19O4P 3-methylphenyl 4-methylphenyl phenyl phosphate: C20H19O4P
- IUPAC Name:
- Reaction mass of 3-methylphenyl diphenyl phosphate, 4-methylphenyl diphenyl phosphate, bis(3-methylphenyl) phenyl phosphate, 3-methylphenyl 4-methylphenyl phenyl phosphate and triphenyl phosphate
- Reference substance name:
- chemical name: Diphenyl tolyl phosphate MCS
- IUPAC Name:
- chemical name: Diphenyl tolyl phosphate MCS
- Details on test material:
- Santicizer 140= monotolyldiphenyl phosphate
Constituent 1
Constituent 2
Method
- Details on study design:
- no data
- Exposure assessment:
- not specified
Results and discussion
Any other information on results incl. tables
The substance was found to be moderately irritating.
Applicant's summary and conclusion
- Executive summary:
In a patch test the test substance was tested in 15 -30 human subjects. Sensitation tests were performed two weeks after the primary irritation test. The test substance was not found to have a sensitizing effect and was found to be moderately irritating.
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