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EC number: 945-730-9
CAS number: -
Alopezia, reduced body weight with 0.2 ml and higher doses
dose dependant), increased liver weight, paralysis in the
0.4, 0.6 and 0.8 ml-groups, microscopical up to 0.2 ml no effects in the
liver, with 0.4 and 0.6 ml hyperemia and
fatty liver changes, with 0.8 ml liver cell necrosis;
edema of the spinal cord in the high dose groups,
hyperplasia and necrosis of the adrenal glands (purity not known).
Diphenyl cresyl phosphate (purity not known) in olive oil was applied to
the shaved skin (3 cm2 exposed area, position not stated) of groups of
four guinea pigs (strain and sex not given) daily for 73 days.
Administered doses were equivalent to approximately 120, 240, 480, 720
or 960 mg/kg bw/day.
All guinea pigs, including those in the control group, showed slight
erythema with scale formation; this was attributed to the presence of
the vehicle, olive oil. There was a dose-dependent increase in alopecia
from 240 mg/kg bw/day, and body weight gains were reduced in the two
highest doses. At 480 mg/kg bw/day, hind limb paralysis was observed in
two animals. At doses greater than 480 mg/kg bw/day, paralysis of the
hind limbs and lower portions of the back muscles were observed in all
animals (the time of onset of signs of paralysis were not given).
Effects on the liver were apparent from 480 mg/kg bw/day. At 720 mg/kg
bw/day, the severity of hepatic effects increased. The highest dose
caused all of these effects plus necrosis of hepatocytes and complete
glycogen depletion. At doses of 480 mg/kg bw/day or above, hyperplasia,
formation of fatty cysts, lipid vacuoles in the cortex and hyperaemia in
the cortex and medulla of the adrenal glands were noted. The NOAEL for
this study was considered to be the lowest dose tested; 120 mg/kg bw/day
(Geffke et al. 1970, cited in BG Chemie 2000).
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