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EC number: 232-190-8 | CAS number: 7789-79-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.821 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 75
- Dose descriptor starting point:
- NOAEL
- Value:
- 35.2 mg/kg bw/day
- Modified dose descriptor starting point:
- other: NAEC
- Value:
- 61.6 mg/m³
- Explanation for the modification of the dose descriptor starting point:
Inhalation should not be a preferred route for absorption. Original value is NOAEL 35.2 mg/kg bw/day, subacute toxicity in rat by oral administration. Allometric scaling from rat to human is 4. The result is multiplied by 70 kg considered as the average weight of a human being (bw) and divided by 10 m3/person considered as the average volume that is breathed in a 8 h exposure.
NAEC = [(35.2 mg/kg bw/ 4)*70 kg bw]/10 m3/person= 61.6 mg/m3 bw
- AF for dose response relationship:
- 1
- Justification:
- Not necessary
- AF for differences in duration of exposure:
- 6
- Justification:
- From subacute to chronic
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Already considered (4)
- AF for other interspecies differences:
- 2.5
- Justification:
- Correction for possible differences in the ADME
- AF for intraspecies differences:
- 5
- Justification:
- Worker population
- AF for the quality of the whole database:
- 1
- Justification:
- Good quality and reliability
- AF for remaining uncertainties:
- 1
- Justification:
- No further uncertainties
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.173 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 300
- Dose descriptor starting point:
- NOAEL
- Value:
- 35.2 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 352 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
Skin absorption can be considered as negligible and never higher 10 % than oral absorption. A starting value of 10x the NOAEL measured in a oral study is considered.
- AF for dose response relationship:
- 1
- Justification:
- Not necessary
- AF for differences in duration of exposure:
- 6
- Justification:
- From subacute to chronic
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- From rat to human
- AF for other interspecies differences:
- 2.5
- Justification:
- Correction for possible differences in the ADME
- AF for intraspecies differences:
- 5
- Justification:
- Workers
- AF for the quality of the whole database:
- 1
- Justification:
- Good quality and reliability
- AF for remaining uncertainties:
- 1
- Justification:
- No further uncertainties
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Additional information - workers
Calcium hypophosphite is classified H302 (acute oral toxicity cat.4) and H319 (eye irritation cat.2).
The assessment is done based on repeated dose toxicity studies (NOAEL 28 days rat = 35.2 mg/kg bw/day).
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.205 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 150
- Dose descriptor starting point:
- NOAEL
- Value:
- 35.2 mg/kg bw/day
- Modified dose descriptor starting point:
- other: NAEC
- Value:
- 30.8 mg/m³
- Explanation for the modification of the dose descriptor starting point:
Inhalation should not be a preferred route for absorption. Original value is NOAEL 35.2 mg/kg bw, subacute toxicity in rat by oral administration. Allometric scaling from rat to human is 4. The result is multiplied by 70 kg considered as the average weight of a human being (bw) and divided by 20 m3/person considered as the average volume that is breathed by general population.
NAEC = [(35.2 mg/kg bw / 4)*70 kg bw]/20 = 30.8 mg/m3 bw
- AF for dose response relationship:
- 1
- Justification:
- not necessary
- AF for differences in duration of exposure:
- 6
- Justification:
- From subacute to subchronic
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Already considered (4)
- AF for other interspecies differences:
- 2.5
- Justification:
- Correction for possible differences in the ADME.
- AF for intraspecies differences:
- 10
- Justification:
- General population
- AF for the quality of the whole database:
- 1
- Justification:
- Original data from GLP study performed on the substance itself.
- AF for remaining uncertainties:
- 1
- Justification:
- No other concern derived from other studies.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.587 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 600
- Dose descriptor starting point:
- NOAEL
- Value:
- 35.2 mg/kg bw/day
- Modified dose descriptor starting point:
- other: modified starting point
- Value:
- 352 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
Skin absorption can be considered as negligible and never higher 10 % than oral absorption. A starting value of 10x the NOAEL measured in a oral study is considered.
- AF for dose response relationship:
- 1
- Justification:
- not necessary
- AF for differences in duration of exposure:
- 6
- Justification:
- From subacute to chronic.
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- From rat to human.
- AF for other interspecies differences:
- 2.5
- Justification:
- Correction for possible differences in the ADME.
- AF for intraspecies differences:
- 10
- Justification:
- General population
- AF for the quality of the whole database:
- 1
- Justification:
- Original data from a GLP study performed on the substance itself.
- AF for remaining uncertainties:
- 1
- Justification:
- No other concerm from other studies.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.058 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 600
- Dose descriptor starting point:
- NOAEL
- Value:
- 35.2 mg/kg bw/day
- AF for dose response relationship:
- 1
- Justification:
- Not necessary
- AF for differences in duration of exposure:
- 6
- Justification:
- From subacute to chronic.
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- From rat to human.
- AF for other interspecies differences:
- 2.5
- Justification:
- Correction for possible differences in the ADME.
- AF for intraspecies differences:
- 10
- Justification:
- General population
- AF for the quality of the whole database:
- 1
- Justification:
- Original data from a GLP study performed on the substance itself.
- AF for remaining uncertainties:
- 1
- Justification:
- No other concerm from other studies.
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.352 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 100
- DNEL extrapolated from long term DNEL
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 35.2 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
No extrapolation.
- AF for dose response relationship:
- 1
- Justification:
- Not necessary
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- not necessary
- AF for other interspecies differences:
- 2.5
- Justification:
- Correction for possible differences in the ADME.
- AF for intraspecies differences:
- 10
- Justification:
- General population.
- AF for the quality of the whole database:
- 1
- Justification:
- Original data from a GLP study performed on the substance itself.
- AF for remaining uncertainties:
- 1
- Justification:
- No other concerm from other studies.
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Additional information - General Population
Exposure of general population is not expected due to the peculiar use of the substance. Calcium hypophospite will not be available to general population as it is only included in polymeric matrices.
DNELs were derivied for precautionary principle.
Even though calcium may have an effect for acute exposure, there is no concern for repeated dose exposure at lower concentration as both calcium and hypophosphiye ions have a very low toxicological profile.
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