Registration Dossier
Registration Dossier
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EC number: 232-190-8 | CAS number: 7789-79-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Calcium phosphinate
- EC Number:
- 232-190-8
- EC Name:
- Calcium phosphinate
- Cas Number:
- 7789-79-9
- Molecular formula:
- Ca.2H3O2P
- IUPAC Name:
- calcium phosphinate
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Remarks:
- minimal moistened with doubly distilled water
- Controls:
- not required
- Amount / concentration applied:
- As is.
- Duration of treatment / exposure:
- 4 h
- Observation period:
- 72 h
- Number of animals:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 1h
- Score:
- > 0 - < 1
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 1h
- Score:
- ca. 0
- Irritant / corrosive response data:
- Not irritant
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified based on CLP Regulation (EC no. 1272/2008)
- Conclusions:
- 2 out of 3 animals had erythema score 1. Erythema disappeared after 24 h in one animals and after 48 h in the other one.
No edema was recorded.
No other sign of toxicity was recorded. - Executive summary:
3 White New Zealand Rabbit were tested in vivo for skin irritation according to OECD 404 in a semiocclusive exposure.
2 out of 3 animals had erythema score 1. Erythema disappeared after 24 h in one animals and after 48 h in the other one. No edema was recorded No other sign of toxicity was recorded.
The substance is not irritating according to the CLP Regulation (EC no. 1272/2008).
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