Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 232-190-8 | CAS number: 7789-79-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Calcium phosphinate
- EC Number:
- 232-190-8
- EC Name:
- Calcium phosphinate
- Cas Number:
- 7789-79-9
- Molecular formula:
- Ca.2H3O2P
- IUPAC Name:
- calcium phosphinate
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Remarks:
- minimal moistened with doubly distilled water
- Controls:
- not required
- Amount / concentration applied:
- As is.
- Duration of treatment / exposure:
- 4 h
- Observation period:
- 72 h
- Number of animals:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 1h
- Score:
- > 0 - < 1
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 1h
- Score:
- ca. 0
- Irritant / corrosive response data:
- Not irritant
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified based on CLP Regulation (EC no. 1272/2008)
- Conclusions:
- 2 out of 3 animals had erythema score 1. Erythema disappeared after 24 h in one animals and after 48 h in the other one.
No edema was recorded.
No other sign of toxicity was recorded. - Executive summary:
3 White New Zealand Rabbit were tested in vivo for skin irritation according to OECD 404 in a semiocclusive exposure.
2 out of 3 animals had erythema score 1. Erythema disappeared after 24 h in one animals and after 48 h in the other one. No edema was recorded No other sign of toxicity was recorded.
The substance is not irritating according to the CLP Regulation (EC no. 1272/2008).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
