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EC number: 232-190-8 | CAS number: 7789-79-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: ECVAM DB-ALM INVITTOX Protocol 96
- Deviations:
- not applicable
- Remarks:
- The study was performed before the publication of the protocol, even though it is fully compliant.
- GLP compliance:
- no
Test material
- Reference substance name:
- Calcium phosphinate
- EC Number:
- 232-190-8
- EC Name:
- Calcium phosphinate
- Cas Number:
- 7789-79-9
- Molecular formula:
- Ca.2H3O2P
- IUPAC Name:
- calcium phosphinate
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals / tissue source
- Details on test animals or tissues and environmental conditions:
- Hen's egg
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- Undiluted
- Duration of treatment / exposure:
- 1 min and 3 min
- Number of animals or in vitro replicates:
- 1 egg - 1 min
3 eggs - 3 min - Details on study design:
- The present study refers to the same publication referred into the Invittox protocol:
Spielmann et al. (1991). Interlaboratory assessment of alternatives to the Draize eye irritation test in Germany. Toxic.in vitro 5(6) 539-542
Results and discussion
In vitro
Resultsopen allclose all
- Irritation parameter:
- other: Haemorrhagia
- Value:
- ca. 1
- Irritation parameter:
- other: Lysis
- Value:
- ca. 0
- Irritation parameter:
- other: Coagulation
- Value:
- ca. 2.3
In vivo
- Irritant / corrosive response data:
- Score is based on the addition of the three effects. Total score is: 3.3.
Grading of effects observed after test substance removal by washing.
Any other information on results incl. tables
Grading:
0 = no reaction
1 = slight
2 = moderate
3 = severe
Applicant's summary and conclusion
- Interpretation of results:
- other: Eye Irrit. 2 based on CLP Regluation (EC no. 1272/2008)
- Conclusions:
- Ca(H2PO2)2 may cause severe eye damage.
- Executive summary:
Calcium hypophosphite was analysed in vitro with the HET-CAM in vitro corrosion test. This is an accepted methods that is based on the effect of the test item on hen's eggs.
The final score is the sum of the effects on haemorragia, Lysis and coagulation.
Final score after 3 min is 3.3 which corresponds to severe eye irritant.
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