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EC number: 232-190-8 | CAS number: 7789-79-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1990
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Remarks:
- Review
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Hypophosphite: A review
- Author:
- Rhodehamel, Pierson and Leifer
- Year:
- 1 990
- Bibliographic source:
- Journal of food protection, Vol. 53(6): 513-518
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The review considers a lot of studies performed on animals by oral or intraperitoneal administration.
- GLP compliance:
- no
Test material
- Reference substance name:
- Hypophosphite
- IUPAC Name:
- Hypophosphite
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- other: pigs, rats, cows
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: Orally or intraperitoneal
- Vehicle:
- not specified
- Details on exposure:
- This is a review paper. No details on testing protocol is provided.
- Duration and frequency of treatment / exposure:
- This is a review paper. No details on testing protocol is provided.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
This is a review paper. No details on testing protocol is provided.
- No. of animals per sex per dose / concentration:
- This is a review paper. No details on testing protocol is provided.
- Control animals:
- not specified
Results and discussion
Main ADME resultsopen allclose all
- Type:
- excretion
- Results:
- Hypophosphite is completely excreted through the urine in 24 h.
- Type:
- metabolism
- Results:
- Hypophosphite is excreted unchanged. No metabolism occurs.
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- Hypophosphite is excreted unchanged. There is no formation of metabolites.
Applicant's summary and conclusion
- Conclusions:
- Hypophosphite is completely excreted through the urine in 24 h. No metabolic modification occors.
Bioavailability of Calcium hypophosphite is very low because it probably combines with phosphate present in food and precipitates. - Executive summary:
Hypophosphites were intensively investigated in the end of last century because they were considered a possible dietary supplements to provide extra phosphorous to the organism.
When hypophosphite were given orally or intraperitoneally to pigs rats cows and eventually human volunteers, the entire amount was excreted in the urine within 24h.
As a conclusion, hypophosphite has a very low toxicological profile but it cannot be used as dietary supplement due to the very low (or nothing) bioavailability of phosphorous.
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