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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1990
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Remarks:
Review

Data source

Reference
Reference Type:
review article or handbook
Title:
Hypophosphite: A review
Author:
Rhodehamel, Pierson and Leifer
Year:
1990
Bibliographic source:
Journal of food protection, Vol. 53(6): 513-518

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The review considers a lot of studies performed on animals by oral or intraperitoneal administration.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder

Test animals

Species:
other: pigs, rats, cows
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
other: Orally or intraperitoneal
Vehicle:
not specified
Details on exposure:
This is a review paper. No details on testing protocol is provided.
Duration and frequency of treatment / exposure:
This is a review paper. No details on testing protocol is provided.
Doses / concentrations
Remarks:
Doses / Concentrations:
This is a review paper. No details on testing protocol is provided.
No. of animals per sex per dose:
This is a review paper. No details on testing protocol is provided.
Control animals:
not specified

Results and discussion

Main ADME resultsopen allclose all
Type:
excretion
Results:
Hypophosphite is completely excreted through the urine in 24 h.
Type:
metabolism
Results:
Hypophosphite is excreted unchanged. No metabolism occurs.

Metabolite characterisation studies

Metabolites identified:
yes
Details on metabolites:
Hypophosphite is excreted unchanged. There is no formation of metabolites.

Applicant's summary and conclusion

Conclusions:
Hypophosphite is completely excreted through the urine in 24 h. No metabolic modification occors.
Bioavailability of Calcium hypophosphite is very low because it probably combines with phosphate present in food and precipitates.
Executive summary:

Hypophosphites were intensively investigated in the end of last century because they were considered a possible dietary supplements to provide extra phosphorous to the organism.

When hypophosphite were given orally or intraperitoneally to pigs rats cows and eventually human volunteers, the entire amount was excreted in the urine within 24h.

As a conclusion, hypophosphite has a very low toxicological profile but it cannot be used as dietary supplement due to the very low (or nothing) bioavailability of phosphorous.