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Administrative data

Endpoint:
density, other
Remarks:
Density
Type of information:
experimental study
Adequacy of study:
key study
Study period:
27/5/2016-27/5/2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
Experimental test result performed using standard OECD test guidelines.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2016
Report date:
2016

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 109 (Density of Liquids and Solids)
Principles of method if other than guideline:
The density of test item 2-[7-(diethylamino)-2-oxo-2H-1-benzopyran-3-yl)-1,3-dimethyl-1H-benzimidazolium chlorine (CAS No. 29556-33-0) was determined following OECD guideline 109 and according to the method recommended in the International Pharmacopoeia, fourth Edition, 2014.
GLP compliance:
no
Type of method:
pycnometer method

Test material

Constituent 1
Chemical structure
Reference substance name:
2-[7-(diethylamino)-2-oxo-2H-1-benzopyran-3-yl]-1,3-dimethyl-1H-benzimidazolium chloride
EC Number:
249-694-9
EC Name:
2-[7-(diethylamino)-2-oxo-2H-1-benzopyran-3-yl]-1,3-dimethyl-1H-benzimidazolium chloride
Cas Number:
29556-33-0
Molecular formula:
C22H24N3O2.Cl
IUPAC Name:
2-[7-(diethylamino)-2-oxo-2H-chromen-3-yl]-1,3-dimethyl-2,3-dihydro-1H-3,1-benzimidazol-1-ium chloride
Test material form:
solid: particulate/powder
Details on test material:
- Name of test material (as cited in study report): 2-[7-(diethylamino)-2-oxo-2H-1-benzopyran-3-yl]-1,3-dimethyl-1H-benzimidazolium chloride
- Molecular formula: C22H24N3O2.Cl
- Molecular weight: 397.904 g/mol
- Smiles notation: c1([n+](c2c(n1C)cccc2)C)c1c(oc2c(c1)ccc(c2)N(CC)CC)=O.[ClH-]
- InChl: 1S/C22H24N3O2.ClH/c1-5-25(6-2)16-12-11-15-13-17(22(26)27-20(15)14-16)21-23(3)18-9-7-8-10-19(18)24(21)4;/h7-14H,5-6H2,1-4H3;1H/q+1;/p-1
- Substance type: Organic
- Physical state: Solid
Specific details on test material used for the study:
- Name of test material (as cited in study report): 2-[7-(diethylamino)-2-oxo-2H-1-benzopyran-3-yl]-1,3-dimethyl-1H-benzimidazolium chloride
- Molecular formula (if other than submission substance): C22H24N3O2.Cl
- Molecular weight (if other than submission substance): 347.4159
- Smiles notation (if other than submission substance): c1(c2c(oc3c(c2)ccc(N(CC)CC)c3)=O)nc2ccccc2n1C
- InChl (if other than submission substance): 1S/C21H21N3O2/c1-4-24(5-2)15-11-10-14-12-16(21(25)26-19(14)13-15)20-22-17-8-6-7-9-18(17)23(20)3/h6-13H,4-5H2,1-3H3
- Substance type: Organic
- Physical state: Solid

Results and discussion

Densityopen allclose all
Key result
Type:
pour density
Density:
0.465 g/cm³
Temp.:
32 °C
Remarks on result:
other: at 969.1 hPa atmospheric pressure
Key result
Type:
tap density
Density:
0.555 g/cm³
Temp.:
32 °C
Remarks on result:
other: at 969.1 hPa atmospheric pressure

Any other information on results incl. tables

TEST ITEM DESCRIPTION AND RESULTS

Method Details

Observations

Remarks if, any

Guideline

OECD 109

1stReading

2ndReading

 

 

 

Method

Test methods: Pour density and tapped density of powders”recommended inThe International Pharmacopoeia, Fourth Edition, 2014[1]

 

 

Principle of method

Pour Density:It is the ratio of known weight of test item and its volume in graduated glass cylinder.

Tap Density:It is the difference between the volume of test item measured before & after tapping in the graduated glass cylinder.

 

 

Test temperature (°C)

-

32.5

31.6

Atmospheric pressure (in hPa)

-

968.6 hPa

969.6 hPa

Weight of test item(m)

 

20 g

20 g

Volume of measuring cylinder; readability in g

 

250 ml;

2 ml

250ml;

2 ml

Volume of test item without tapping (V)

 

44 ml

42 ml

Volume of test item after tapping ( V1)

After 10 tapping

40 ml

38 ml

 

After 50 tapping

36 ml

36 ml

 

After 100 tapping

36ml

36ml

 

After 250 tapping

----

------

 

After 500 tapping

-------

--------

 

After 750 Tapping

-------

------

Applicant's summary and conclusion

Conclusions:
The mean pour density and tapped density of the test item 2-[7-(diethylamino)-2-oxo-2H-1-benzopyran-3-yl)-1,3-dimethyl-1H-benzimidazolium chlorine (CAS No. 29556-33-0) was found to be 0.4653 g/cm3 and 0.5555 g/cm3 at 32.0°C and 969.1hPa.
Executive summary:

The mean density of test item2-[7-(diethylamino)-2-oxo-2H-1-benzopyran-3-yl)-1,3-dimethyl-1H-benzimidazolium chlorine (CAS No. 29556-33-0)was determined following OECD Guideline 109 and according to theOECD guideline 109 and according to themethod recommended in the International Pharmacopoeia, fourth Edition, 2014using bulk density apparatus.The mean pour density and tapped density of the test item was found to be 0.4653g/cm3and  0.5555 g/cm3at 32.0 °C and  969.1hPa.

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