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Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data from authoritative databases

Data source

Reference
Reference Type:
other: Authoritative data base
Title:
Determination of Eye Irritation Potential of the test chemical
Author:
IFA (GESTIS)
Year:
2011
Bibliographic source:
GESTIS - Substance Database (Information system on hazardous substances of the Berufsgenossenschaften); 2011

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To assess the ocular irritation potential of the test chemical
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
N,N-diethylaniline
EC Number:
202-088-8
EC Name:
N,N-diethylaniline
Cas Number:
91-66-7
Molecular formula:
C10H15N
IUPAC Name:
N, N-diethylaniline
Test material form:
liquid
Remarks:
Oily liquid
Details on test material:
- Name of test material: N,N-diethylaniline
- Substance type: Organic
- Physical state: Liquid
Specific details on test material used for the study:
Name of test material: N,N-diethylaniline
Molecular formula:C10H15N
Molecular weight: 146.24 g/mol
- Substance type: Organic
- Physical state: Liquid

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
no data
Duration of treatment / exposure:
no data
Observation period (in vivo):
no data
Duration of post- treatment incubation (in vitro):
no data
Number of animals or in vitro replicates:
no data

Results and discussion

In vitro

Other effects / acceptance of results:
no data available

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: not specified
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No irritation was observed

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:
Undiluted N,N diethylaniline, did not induce any irritation to rabbit eyes.
Executive summary:

The ocular irritation potential of the N,N diethylaniline was assessed by performing rabbit eye test. Undiluted N,N diethylaniline, did not induce any irritation to rabbit eyes. Hence N,N diethylaniline  can be considered as a non irritant.