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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data from secondary source

Data source

Reference
Reference Type:
secondary source
Title:
Acute oral toxicity study in Rat for CAS no: 734-88-3
Author:
U.S .National library of medicine
Year:
2017
Bibliographic source:
ChemID plus A TOXNET DATABASE.2017

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute oral toxicity study of ethyl 5,6-benzocoumarin-3-carboxylate was performed in Rat
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethyl 5,6-benzocoumarin-3-carboxylate
EC Number:
211-997-9
EC Name:
Ethyl 5,6-benzocoumarin-3-carboxylate
Cas Number:
734-88-3
Molecular formula:
C16H12O4
IUPAC Name:
ethyl 5,6-benzocoumarin-3-carboxylate
Details on test material:
- Name of test material (as cited in study report):ethyl 5,6-benzocoumarin-3-carboxylate
- Molecular formula :C16H12O4
- Molecular weight :268.266g/mole
- Substance type:organic
Specific details on test material used for the study:
- Name of test material (as cited in study report):ethyl 5,6-benzocoumarin-3-carboxylate
- Molecular formula :C16H12O4
- Molecular weight :268.266g/mole
- Substance type:organic

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data available

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data available
Doses:
1580mg/kg bw
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 580 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50% mortality was observed
Mortality:
50% mortality was observed
Clinical signs:
other: Behavioural changes like excitement, altered sleep time (including change in righting reflex) and muscle contraction or spasticity were observed in treated rats.
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
LD50 was considered to be 1580mg/kg bw. When rats were treated with ethyl 5,6-benzocoumarin-3-carboxylate (734-88-3) orally.
Executive summary:

Acute oral toxicity study was done in rat usingethyl 5,6-benzocoumarin-3-carboxylate (734-88-3). Test material in dose concentration 1580mg/kg bw was administered orally. 50% mortality was observed .Clinical signs asbehavioural changes like excitement, altered sleep time (including change in righting reflex)and muscle contraction or spasticity were observed in treated rats. Hence,LD50 was considered to be 1580mg/kg bw. When rats were treated withethyl 5,6-benzocoumarin-3-carboxylate (734-88-3) orally.