Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-865-4 | CAS number: 111-40-0
Carcinogenicity
Administrative data
Description of key information
Two chronic dermal studies (one key, one supporting) in male C3H/HeJ Mice were conducted to determine the potential of diethylene triamine (DETA) to cause skin tumors. Both high purity and commercial grade were used in these evaluations.
Key value for chemical safety assessment
Carcinogenicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 56.3 mg/kg bw/day
Justification for classification or non-classification
Diethylene triamine is not carcinogenic via the dermal route and not classifiable under GHS.
Additional information
Male C3H/HeJ mice were administerd 25 ul of a 5% solution of DETA three times per week throughout their lifetime. The Mean Survival time was 587 and 662 days for the purified and commercial grade DETA. There were no treatment related tumors of the skin in any of the mice. Gross pathology and histologic analysis of kidney, urinary bladder, stomach, liver, skin, thyroids, adrenals, heart, spleen, mesenteric lymph node, bronchi lymph node, pancreatic lymph node, mediastinum, lung prostate, and seminal vesicles did not show any treatment related tumors.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
