Registration Dossier
Registration Dossier
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EC number: 203-865-4 | CAS number: 111-40-0
Endpoint summary
Administrative data
Description of key information
Skin Irritation: There was one key study and one supporting study identified regarding the skin irritation potential of diethylene triamine in rats.
Eye Irritation: There was one key study and one supporting study identified concerning the eye irritation potential of diethylene triamine on the rabbit eye.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
The two studies indicate severe skin damage after treatment with diethylene triamine. After one minute of exposure, skin appeared partly necrotic with marginal reddening.
Two studies indicated severe irreversible corneal damage up through 8 days of observation post-administration with DETA in both washed and unwashed eyes.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: highly corrosive
Justification for classification or non-classification
DETA has a GHS classification as a Category 1B skin irritant based on the Annex 6 classification.
DETA has a GHS classification as a Category 1 eye irritant.
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