Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)
Additional information:

In the LLNA DETA was applied to the ears of mice at concentrations up to 10%. Exposure to DETA provoked stimulation indices of 3.3 and 3.5 at 5% and 10%, respectively. The EC 3 was calculated at 3.9%. All three guinea pig maximization tests confirm that DETA is a potential sensitizer.

Migrated from Short description of key information:
One Local Lymph Node Assay (key study) and two guinea pig maximization tests (one key and two supporting) were available to evaluate the sensitization potential of diethylene triamine.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

Cytokine fingerprinting (interferon gamma, interleukin 4 and interleukin 10) was used for the identification of chemicals that had the potential to cause allergic sensitization of the respiratory tract. Cytokine fingerprinting, a method which has been shown to distinguish between contact and respiratory chemical allergens as a function of LNC cytokine production patterns induced in mice by topical administration of the test chemical. Although DETA was positive in the local lymph node assay, it failed to provoke significant cytokine production as judged by cytokine fingerprinting. Although this produces evidence for the lack of respiratory sensitization of DETA is not conclusive.

Justification for classification or non-classification

DETA is a sensitizing agent and can be classified as a category 1B skin sensitizer.

DETA is not classifiable as a respiratory sensitizer.