Registration Dossier
Registration Dossier
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EC number: 200-849-9 | CAS number: 75-21-8
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicity of Ethylene Oxide Determined on Experimental Animals
- Author:
- Hollingsworth, R.L. et al.
- Year:
- 1 956
- Bibliographic source:
- A.M.A. Arch. Ind. Health, Vol 13, 217-227 (1956)
Materials and methods
- Principles of method if other than guideline:
- Subacute oral study in rats
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Ethylene oxide
- EC Number:
- 200-849-9
- EC Name:
- Ethylene oxide
- Cas Number:
- 75-21-8
- Molecular formula:
- C2H4O
- IUPAC Name:
- oxirane
- Test material form:
- liquid
- Details on test material:
- Purity minimum 99.7%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Duration of treatment / exposure:
- 21 and 30 days
- Frequency of treatment:
- 5 d/wk (15 and 22 dosages)
Doses / concentrations
- Remarks:
- Doses / Concentrations:
15 x 100 mg/kg, 22 x 30 mg/kg and 10 x 3 mg/kg
Basis:
- Control animals:
- yes
- Details on study design:
- Post-exposure period: no data
Results and discussion
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 30 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- female
Target system / organ toxicity
- Critical effects observed:
- yes
- Lowest effective dose / conc.:
- 100 mg/kg bw/day (nominal)
- System:
- gastrointestinal tract
- Organ:
- liver
- stomach
- Treatment related:
- yes
- Dose response relationship:
- yes
- Relevant for humans:
- not specified
Any other information on results incl. tables
The 21-day exposure of 100 mg/kg showed a clear weight reduction, irritation of the stomach and slight liver damage.
The 30-day exposure of 30 mg/kg and 3 mg/kg showed no visible damage regarding growth, hematology, organ weights as well as macroscopic and histological changes.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
