Registration Dossier
Registration Dossier
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EC number: 203-868-0 | CAS number: 111-42-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study meets basic scientific principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 966
- Report date:
- 1966
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- 5 rats per sex were dosed with 200 - 3200 mg/kg bw and observed up to 14 days
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2,2'-iminodiethanol
- EC Number:
- 203-868-0
- EC Name:
- 2,2'-iminodiethanol
- Cas Number:
- 111-42-2
- Molecular formula:
- C4H11NO2
- IUPAC Name:
- 2,2'-iminodiethanol
- Details on test material:
- - Name of test material (as cited in study report): Diethanolamine substance-No. XV/306
- no further data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: US rats
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 2 and 20%
- Amount of vehicle (if gavage): 5, 6.25, 8.0, 10.0, 12.5 ccm/kg bw - Doses:
- 200, 800, 1000, 1250, 1600, 2000, 2500, 3200 mg/kg bw
- No. of animals per sex per dose:
- 5 males, 5 females;
2000 and 2500 mg/kg bw dosing groups: only 5 males tested each - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: daily on working days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, gross pathology, histopathology
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 100 mg/kg bw
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 2 500 mg/kg bw
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 600 mg/kg bw
- Mortality:
- 200 to 1000 mg/kg dosing group: no death occurred;
1250 mg/kg dosing group: 5/5 females died on day 4 (2 animals) and on day 5 (3 animals)
1600 mg/kg dosing group: 5/5 females died on day 5
2000 mg/kg dosing group: no death occurred
2500 mg/kg dosing group: 2/5 males died on day 5
3200 mg/kg dosing group: 5/5 females died within 48 hours; 5/5 males died within 7 days (3/5 died within 48 hours) - Clinical signs:
- other: dyspnea, tumbling, staggering gait, twitches, saltation convulsions, dyspnoea, abdominal lateral position, scrubby coat, anacasm to chew,
- Gross pathology:
- hydrothorax, local adhesions of the gut; signs of irritation on gastro-intestinal tract
Any other information on results incl. tables
Survival of rats after oral application of various doses of diethanolamine
Dose (mg/kg) |
Concentration in vehicle (%) |
No. of animals |
sex |
No. of animals died within |
||||
1h |
24h |
48h |
7d |
14d |
||||
3200 |
20 |
5 |
males |
1/5 |
1/5 |
3/5 |
5/5 |
- |
5 |
females |
0/5 |
3/5 |
5/5 |
5/5 |
- |
||
2500 |
20 |
5 |
males |
0/5 |
0/5 |
0/5 |
2/5 |
2/5 |
females |
||||||||
2000 |
20 |
5 |
males |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
females |
0/5 |
0/5 |
0/5 |
0/5 |
- |
|||
1600 |
20 |
5 |
males |
0/5 |
0/5 |
0/5 |
5/5 |
- |
5 |
females |
0/5 |
0/5 |
0/5 |
0/5 |
- |
||
1250 |
20 |
5 |
males |
0/5 |
0/5 |
0/5 |
0/5 |
- |
5 |
females |
0/5 |
0/5 |
0/5 |
5/5 |
- |
||
1000 |
20 |
5 |
males |
0/5 |
0/5 |
0/5 |
0/5 |
- |
5 |
females |
0/5 |
0/5 |
0/5 |
0/5 |
- |
||
600 |
20 |
5 |
males |
0/5 |
0/5 |
0/5 |
0/5 |
- |
5 |
females |
0/5 |
0/5 |
0/5 |
0/5 |
- |
||
200 |
2 |
5 |
males |
0/5 |
0/5 |
0/5 |
0/5 |
- |
5 |
females |
0/5 |
0/5 |
0/5 |
0/5 |
- |
||
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
