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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Basic data given, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1956
Report Date:
1956

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Principles of method if other than guideline:
Inhalation-risk test (IRT)
GLP compliance:
no
Test type:
other: Inhalation-risk test (IRT)

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): substance-No. V/77, name: Diethanolamine
- Physical state: solid
- Analytical purity: pure sale product

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
other: unchanged (no vehicle)
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
8 h
Concentrations:
mean substance concentration: 0.2 mg/l air (calculated by the weight loss of the test substance over the time of exposure)
No. of animals per sex per dose:
3 males and 3 females
Control animals:
no
Details on study design:
- Duration of observation period following administration: 7 days
- Frequency of observations and weighing: before the exposure to the vapour and at the end of the observation period
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, histopathology

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC0
Effect level:
0.2 mg/L air
Exp. duration:
8 h
Remarks on result:
other: mean substance concentration: 0.2 mg/l air (calculated by the weight loss of the test substance over the time of exposure)
Mortality:
no death occurred (0/6)
Clinical signs:
other: no clinical signs reported
Gross pathology:
nothing abnormal detected

Any other information on results incl. tables

No LC50 value defined; Substance concentration in the vapour was determined by weighing the amount of substance in the substance column before and after the exposure period and calculating the mean concentration per liter air over the whole exposure period.

Applicant's summary and conclusion