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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Based on lowest reliable acute toxicity values for aquatic species diethanolamine is considered to be toxic for aquatic organisms:

Additional information

Short-term toxicity to fish

The lowest effect value was determined in a guideline study (Environment Canada EPS 1/RM/9, 1990/1996) with Oncorhynchus mykiss. The 96-h LC50 was 460 mg/L (nominal, analytically verified; PTAC, 2006).

Based on this result, diethanolamine is with high probability acutely not harmful to fish.


Long-term toxicity to fish

no data available


Short-term toxicity to aquatic invertebrates

A static acute immobilisation study performed according to ASTM Standard E729-80 with Ceriodaphnia dubia was selected as key study (Cowgill et al., 1985). The 48-h EC50 was determined to be 30.1 mg/L.

Based on this result, diethanolamine is considered to be acutely harmful to aquatic invertebrates.


Long-term toxicity to aquatic invertebrates

The long-term toxicity of diethanolamine on aquatic invertebrates was assessed in a semi-static study conducted according to the draft EEC guideline XI/681/86 "Prolonged toxicity study with Daphnia magna: Effects on reproduction" (BASF AG, 1992) following GLP and with analytically verified test concentrations. The effect values were recalculated using ToxRat Professional v2.10. The EC10 after 21 days of exposure based on reproduction was determined to be 1.05 mg/L (nominal).

It can be concluded that long-term effects on aquatic invertebrates are not to be expected


Toxicity to aquatic algae and cyanobacteria

The most sensitive result was obtained in a GLP study following the US EPA algal assay bottle test 600/9-78-018 (1978) and using the green algae Pseudokirchneriella subcapitata (formerly Selenastrum capricornutum) (DOW Chemical, 1982).

Test 1: The 72-h ErC10 was recalculated to be 1.4 mg/L; the 72-h ErC50 was determined to be 9.5 mg/L. Test 2: The 72-h ErC10 was recalculated to be 1.1 mg/L; the 72-h ErC50 was determined to be 19 mg/L. Results of test 1 and test 2 were re-evaluated by using ToxRat Professional v2.10.

Based on these results diethanolamine is considered to be acutely toxic for aquatic algae