Registration Dossier

Administrative data

Description of key information

No measured data are available for 2-methyl-1-heptanol so the data have been read-across from a structural analogue, the linear isomer octan-1-ol. 
The acute oral key study in rat reports an LD50 of >5000 mg/kg for 1-octanol when applied as an aqueous solution (Henkel 1981; rel 2). The LD50 value of >5600 mg/m3 is reported in the key inhalation study in response to a 4 hour exposure to vapour (Amoco 1988; rel 2). The key study for acute dermal toxicity in rabbit found the LD50 value to be 2000-4000 mg/kg (Scientific Associates 1976; rel 2).

Key value for chemical safety assessment

Additional information

The acute key study reports no remarkable gross pathology at necropsy (Henkel 1981). The reliability 2 oral supporting study by Scientific Associates (1965) found the LD50 to be 18240 mg/kg in rat. The remaining supporting studies are reliability 4, and in accordance with the key information. The acute inhalation key study by Amoco (1988) was the only available information, with 5.6 mg/l as the highest dose tested. The clinical signs in response to the 4 hour inhalation exposure included signs of respiratory distress and histopathological evidence of irritation of the respiratory tract. However, the category trend suggests that the linear alcohols have low acute toxicity via the inhalation route. The acute dermal key study reported the most common gross pathological finding to be the erosion of the gastric mucosa (Scientific Associates 1976). The key studies were chosen based on the highest reliability and most recent available study report, and read-across to 2-methyl-1-heptanol.

Justification for classification or non-classification

Based on the available information for the read across substance, 1-octanol, the registration substance 2-methyl-1-heptanol does not require classification for any of the acute toxicity endpoints in accordance with CLP (EC regulation 1272/2008).