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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study well documented, meets generally accepted scientific principles, acceptable for assessment.

Data source

Reference
Reference Type:
publication
Title:
Studies in detoxication 46 The metabolism of aliphatic alcohols. The glucuronic acid conjugation of acyclic aliphatic alcohols.
Author:
Kamil I A et al
Year:
1953
Bibliographic source:
Biochem 53:129-136

Materials and methods

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
n-hexanol; n-heptanol; n-octanol; n-nonanol; n-decanol; n-octadecanol

Results and discussion

Toxicokinetic / pharmacokinetic studies

Toxicokinetic parametersopen allclose all
Toxicokinetic parameters:
half-life 1st:
Toxicokinetic parameters:
half-life 2nd:
Toxicokinetic parameters:
half-life 3rd:

Any other information on results incl. tables

The extra glucuronide excreted as % of dose (average of 3 rabbits, 2 rabbits for *) was as follows:

n-hexanol 10.3%; n-heptanol 5.3%; n-octanol 9.5%; n-nonanol 4.1%; n-decanol* 3.5%; n-octadecanol* 7.6%. It was reported that absorpton of 

n-decanol and n-octadecanol was incomplete and irregular and the alcohol could be isolated in quantity from the faeces.

No further information on other biotransformation pathways of these alcohols was provided.

Applicant's summary and conclusion

Conclusions:
All the primary alcohols investigated form glucuronic acid conjugates which are excreted in the urine. However this was generally <10% of the dose.